CELF1, CUGBP Elav-like family member 1, 10658

N. diseases: 63; N. variants: 11
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease BEFREE A number of genetic variants have previously been identified and associated with the risk of Alzheimer's disease (AD), including rs10838725 in CELF1, rs28834970 in PTK2B, rs17125944 in FERMT2, and rs10410544 in SIRT2 based on genome-wide association studies. 30144538 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease BEFREE The minor allele of rs1057233 (G), within the previously reported CELF1 AD risk locus, showed association with delayed AD onset and lower expression of SPI1 in monocytes and macrophages. 28628103 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease BEFREE Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. 28199971 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease BEFREE Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. 26919393 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease BEFREE Our first GWAS based cross-disorder analysis for AD and obesity suggests that rs10838725 at the locus CELF1 might be relevant for both disorders. 24788522 2014
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease BEFREE Importantly, we also identify the fly orthologs of FERMT2 and CELF1 as Tau modifiers, and these loci have been independently validated as AD susceptibility loci in the latest GWAS meta-analysis. 24067533 2014
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease GWASDB Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.160 GeneticVariation disease GWASCAT Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013