|
Alzheimer's Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Recently, candidate genetic studies revealed the single nucleotide polymorphisms (SNPs) of CUGBP2 (rs2242451) and DNMBP (rs11190305 and rs3740058) associated with Alzheimer's disease (AD).
|
25801238 |
2015 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Multiple studies revealed that CELF2, an RNA binding protein, cooperates synergistically with PTEN as a tumor suppressor in multiple cancers.
|
31241130 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
We identified miR‑95‑3p as a putative therapeutic target and CELF2 as a potential tumor suppressor.
|
26165303 |
2015 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, knockdown of CELF2 in vivo conferred tumor resistance to IR.
|
31020708 |
2019 |
|
Malignant neoplasm of breast
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, the presence of CELF2 hypermethylation in the clinical setting is associated with shorter overall survival of the breast cancer patients carrying this epigenetic lesion.
|
31409895 |
2019 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the current study, we have determined that expression of both COX-2 mRNA and CUGBP2 mRNA are induced in MCF-7 cells, a breast cancer cell line, following exposure to 12 Gy gamma-irradiation.
|
15033780 |
2003 |
|
Malignant Neoplasms
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
Herein, we show that the splicing RNA-binding protein CELF2 is targeted by promoter hypermethylation-associated transcriptional silencing in human cancer.
|
31409895 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Collectively, these results suggest a critical role for miR-20a in glioma cell apoptosis, proliferation, and invasion via the direct targeting of CELF2 and indicate its potential application in cancer therapy.
|
30268547 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CELF2 also increased autophagic flux in CRC.
|
31020708 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We found 512 top-ranked single-nucleotide polymorphisms, among which COL22A1, RGS7, WWOX, and CELF2 were the four susceptibility genes prioritized by all described metrics as the most influential on CRC.
|
30859622 |
2019 |
|
Pancreatic carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we have determined that curcumin modulates the expression of RNA binding protein CUGBP2 to inhibit pancreatic cancer growth.
|
21347286 |
2011 |
|
Pancreatic carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Decreased activity of CUGBP2 could be associated with high chemoresistance and early dissemination of pancreatic cancer through the HO-1- and COX-2-mediated cytoprotective and carcinogenesis pathways.
|
26691217 |
2016 |
|
Malignant neoplasm of pancreas
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we have determined that curcumin modulates the expression of RNA binding protein CUGBP2 to inhibit pancreatic cancer growth.
|
21347286 |
2011 |
|
Malignant neoplasm of pancreas
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Decreased activity of CUGBP2 could be associated with high chemoresistance and early dissemination of pancreatic cancer through the HO-1- and COX-2-mediated cytoprotective and carcinogenesis pathways.
|
26691217 |
2016 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the current study, we have determined that expression of both COX-2 mRNA and CUGBP2 mRNA are induced in MCF-7 cells, a breast cancer cell line, following exposure to 12 Gy gamma-irradiation.
|
15033780 |
2003 |
|
Breast Carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, the presence of CELF2 hypermethylation in the clinical setting is associated with shorter overall survival of the breast cancer patients carrying this epigenetic lesion.
|
31409895 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
Herein, we show that the splicing RNA-binding protein CELF2 is targeted by promoter hypermethylation-associated transcriptional silencing in human cancer.
|
31409895 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Collectively, these results suggest a critical role for miR-20a in glioma cell apoptosis, proliferation, and invasion via the direct targeting of CELF2 and indicate its potential application in cancer therapy.
|
30268547 |
2019 |
|
Familial (FPAH)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia.
|
11414768 |
2001 |
|
Familial (FPAH)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
|
21379329 |
2011 |
|
Autoimmune Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The genes functions were related to a diverse cellular process including: (1) most of these genes were associated with CD4+ T cells functions, particularly related to cellular developments; (2) Ras pathway genes as RANBP10, GMIP, RASGRP2 and ARL5 might be responsible for the abnormal development of CD4+ T cells of SLE; (3) HIG2, TCF7, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI and PIM2 belong to Wnt/beta-catenin way, they could play roles in modulating proliferation and differentiation of T lymphocytes; (4) uncertain viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes as EIF3S8, SH3BGRL3, GPX4, TOSO, PFDN5, BIN1, XIAPAF1, TEGT and CUGBP2 may contribute to over uploading of selfantigens in SLE cells.
|
16143398 |
2006 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.
|
31241130 |
2019 |
|
Hypertrophic Cardiomyopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that CELF1 and CELF2, but not HO-1, were highly expressed in HCM heart samples.
|
30508596 |
2019 |
|
DiGeorge Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We did not find BRUNOL3 mutations in 92 DiGeorge syndrome-like patients without chromosomal deletions and in 8 parents with congenital heart defect children.
|
12110949 |
2002 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CELF2 gene is located on the chromosome 10p arm, a region frequently lost in human cancers, including breast invasive carcinoma, low-grade glioma, and glioblastoma.
|
31241130 |
2019 |