|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effect of variation at the cholesteryl ester transfer protein (CETP) gene locus and in the apolipoprotein (apo) AI-CIII-AIV gene cluster on the susceptibility of individuals with non-insulin-dependent diabetes mellitus (NIDDM) to atherosclerotic vascular disease was studied in 136 male and 122 female patients with NIDDM.
|
7820935 |
1994 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the current study, to elucidate the clinical significance of and atherogenicity in marked HALP, we determined the incidence of atherosclerotic cardiovascular disease (ACD) in patients with marked HALP and characterized the lipoprotein abnormalities in those who had ACD, focusing especially on CETP and HTGL.
|
7583564 |
1995 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition to the apparent antiatherogenic phenotype of human genetic CETP deficiency, high level expression of CETP in transgenic mice leads to accelerated atherosclerosis, illustrating the pro-atherogenic potential of CETP expression.
|
7830031 |
1995 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a separate study, we found an increased susceptibility to dietary atherosclerosis in nonhypertriglyceridemic CETP transgenic mice compared to controls.
|
7560101 |
1995 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
CETP is susceptible to play a proatherogenic role since it mediates a redistribution of plasma cholesterol from lipoproteins associated with a protection against atherosclerosis into the proatherogenic apo B-containing lipoproteins.
|
8964591 |
1996 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cholesteryl ester transfer protein (CETP) has a central role in the metabolism of this lipoprotein and may therefore alter the susceptibility to atherosclerosis.
|
9420339 |
1998 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of two common polymorphisms of CETP, TaqIB in intron 1 and isoleucine 405 to valine (I405-->V) in exon 14, were examined in a sample of 822 men age 18-28 years from 11 countries in Europe who had participated in a study (the European Atherosclerosis Research Study II) of the offspring of myocardial infarction sufferers before the age of 55 years and age-matched control subjects.
|
10092998 |
1999 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that CETP expression reduces atherosclerosis in LCAT-Tg mice by restoring the functional properties of LCAT-Tg mouse HDL and promoting the hepatic uptake of HDL-CE.
|
10601244 |
1999 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
New Zealand White (NZW) rabbits have low plasma total cholesterol concentrations, high cholesteryl ester transfer protein activity, low hepatic lipase (HL) activity, and lack an analogue of human apolipoprotein (apo) A-II, providing a unique system in which to assess the effects of human transgenes on plasma lipoproteins and atherosclerosis susceptibility.
|
10064724 |
1999 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We report here a transgenic atherosclerosis-polygenic hypertension model in Dahl salt-sensitive hypertensive rats that overexpress the human cholesteryl ester transfer protein (Tg[hCETP]DS).
|
10581080 |
1999 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the impact of CETP expression on more advanced forms of atherosclerosis, we have cross-bred the human CETP transgene into the apoE knock-out (apoE0) background with and without concomitant expression of the human apo A-I transgene.
|
10195942 |
1999 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Plasma cholesteryl ester transfer protein has a dual effect on atherosclerosis, depending on the metabolic background.
|
10945721 |
2000 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis.
|
10978256 |
2000 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The significance of CETP in terms of atherosclerosis had been controversial.
|
10998455 |
2000 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the pathophysiological significance of CETP in terms of atherosclerosis has been controversial, the in vitro experiments showed that large CE-rich HDL particles in CETP deficiency are defective in cholesterol efflux.
|
11111094 |
2000 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize the recent advances in this field as well as discussing the significance of CETP in reverse cholesterol transport, a major protective system against atherosclerosis.
|
11086331 |
2000 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cholesteryl ester transfer protein (CETP) is involved in the reverse cholesterol transport and is therefore a candidate gene for atherosclerosis.
|
10619997 |
2000 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have screened the CETP gene for mutations and polymorphisms regulating high density lipoproteins cholesterol (HDL-C) levels and the development of atherosclerosis, and found some polymorphisms (I405V and R451Q) to have minor effects.
|
11454014 |
2001 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the effects of CETP itself and its interaction with HDL-C have not been investigated in hemodialysis patients, who are at high risk for atherosclerosis and generally considered to have decreased reverse cholesterol transport.
|
11431184 |
2001 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography.
|
11689217 |
2001 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We further characterized one of the transgenic strains, CETP-4, by optimizing the experimental condition for the mouse model of atherosclerosis, and found that it would be useful for the development of therapeutics against atherosclerosis.
|
11322777 |
2001 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester (CE) from HDL to apolipoprotein (apo) B-containing lipoproteins and plays a crucial role in reverse cholesterol transport, which is a major protective system against atherosclerosis.
|
11397708 |
2001 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cholesteryl ester transfer protein (CETP) is a key regulating factor of lipid metabolism, and the polymorphism of its gene may therefore be a candidate for modulating the lipid parameters, altering the susceptibility to atherosclerosis in type 2 diabetic subjects.
|
11872695 |
2002 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To study the effects of diabetes on lipoprotein profiles and atherosclerosis in a rodent model, we crossed mice that express human apolipoprotein B (HuB), mice that have a heterozygous deletion of lipoprotein lipase (LPL1), and transgenic mice expressing human cholesteryl ester transfer protein (CETP).
|
12032161 |
2002 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is known about the role of CETP-ovarian hormone interactions in atherogenesis.
|
12518020 |
2003 |