STAG2, stromal antigen 2, 10735

N. diseases: 132; N. variants: 8
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.330 Biomarker disease BEFREE Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma. 27500726 2016
CUI: C0025202
Disease: melanoma
melanoma 		0.330 AlteredExpression disease BEFREE STAG2 encodes a subunit of the cohesion complex that participates in mitotic chromatid separation and was recently found to show low expression and inactivating mutations in Ewing's sarcoma, melanoma and glioblastoma.In the childhood tumor neuroblastoma (NB) segmental chromosomal alterations are associated with poor prognosis whereas tumors displaying whole chromosome gains and losses have a much better prognosis. 24088605 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.330 Biomarker disease BEFREE Recently, somatic mutation of STAG2 gene and loss of STAG2 protein have been reported in glioblastoma, Ewing's sarcoma and melanoma. 22668012 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.330 CausalMutation disease CGI