|
MASP2 Deficiency
|
0.710 |
Biomarker
|
disease |
BEFREE |
Cumulative evidence suggests that MASP-2, and even other components of the LP, are largely redundant in human defenses and that individuals with MASP-2 deficiency do not seem to be particularly prone to infectious or autoimmune diseases.
|
31828694 |
2020 |
|
Tuberculosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Both genotype GC at rs7096206 of MBL genes and genotype TC at rs2273346 and rs6695096 of MASP-2 genes were more prevalent in the TB patient group than the healthy control group (P<0.05, OR 1.393, 1.302 and 1.426 respectively).
|
25887173 |
2015 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Those findings provided an evidence that MASP-2 may be as a newly immunomodulatory in targeting granuloma formation, which displayed a potential protective role in control of tuberculosis.
|
28536447 |
2017 |
|
Tuberculosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Tuberculosis (TB) has been linked with mannose-binding lectin and MASP-2 gene polymorphism.
|
31383674 |
2019 |
|
Tuberculosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Genotype CG at rs7096206 of MBL genes (OR 2.02) and genotype TC at rs6695096 of MASP-2 genes (OR 1.67) were more prevalent in the TB patients than in healthy controls (p<0.05).
|
25312983 |
2014 |
|
Tuberculosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
No relationship between Ficolin-2, Ficolin-3 or MASP-2 genotypes or serum levels and TB were observed.
|
25761428 |
2015 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification.
|
26559095 |
2015 |
|
Hepatitis C
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The haplotype block MASP2*ARDP was associated with protection against HCV infection (OR = 0.49, p = .044) and lower MASP-2 levels in controls (p = .021), while haplotype block AGTDVRC was significantly increased in patients (OR = 7.58, p = .003).
|
29675993 |
2018 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, further functional investigations are necessary to understand the degree of involvement between MASP2 and the HCV susceptibility.
|
21843573 |
2011 |
|
Hepatitis C
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our data do not seem to suggest a role for MBL2 and MASP2 polymorphisms in HCC susceptibility either for HBV-HCV infection-dependent HCC or for HCC raised as a consequence of exposure to different risk factors.
|
18221301 |
2008 |
|
Autoimmune Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Mannan-binding lectin serine protease 2 (MASP-2) mutation was associated with recurrent infections and autoimmune diseases.
|
31383674 |
2019 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Cumulative evidence suggests that MASP-2, and even other components of the LP, are largely redundant in human defenses and that individuals with MASP-2 deficiency do not seem to be particularly prone to infectious or autoimmune diseases.
|
31828694 |
2020 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
A SMAP in the face for cancer.
|
28504652 |
2017 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
This was partly a reflection of higher MBL concentrations and MBL-MASP-2 activity in cancer patients compared with healthy women carrying corresponding genotypes.
|
17131120 |
2007 |
|
Cystic Fibrosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, MBL or MASP-2 levels in serum did not affect the clinical outcome in the cohort of CF patients studied.
|
15654829 |
2005 |
|
Pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Polymorphisms at genes coding for mannose binding lectin (MBL), MBL-associated serine protease 2, Fc-gamma receptors, and surfactant proteins A1, A2, and D were determined, and their potential association with pneumonia was analyzed.
|
25086072 |
2014 |
|
Pneumonia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia.
|
21198752 |
2011 |
|
Rheumatic Fever
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the D105G mutation in the MASP2 gene does not play a major role in the pathogenesis of RF.
|
18295674 |
2008 |
|
Rheumatic Fever
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
MASP2 gene polymorphisms and protein levels seem to play an important role in the development of RF and establishment of RHD.
|
25318078 |
2014 |
|
Rheumatic Heart Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
MASP2 gene polymorphisms and protein levels seem to play an important role in the development of RF and establishment of RHD.
|
25318078 |
2014 |
|
Rheumatic Heart Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The Asp105Gly MASP2 mutation (D105G) was detected by polymerase chain reaction-restriction fragment length polymorphism in 148 patients (43 men and 105 women; mean age 39.1 +/- 14.4 years) with a history of RF, including 106 (73%) with RHD and 42 (27%) without cardiac sequelae, and 129 control subjects (52 men and 77 women, mean age 38.4 +/- 12.2 years).
|
18295674 |
2008 |
|
Septicemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Among neonates, ficolin-1 and MASP-2 levels were elevated in sepsis relative to healthy, but not disease, controls.
|
26850322 |
2016 |
|
Septicemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
On day 7 of life, MASP2 levels in infants developing late-onset sepsis measured before the onset of symptoms were found to be lower, as compared to non-LOS infants.
|
29807983 |
2018 |
|
Systemic Inflammatory Response Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
No differences were observed regarding the frequencies of low-MBL genotypes (O/O and XA/O) and MASP2 polymorphisms between patients with SIRS and healthy controls.
|
20042521 |
2010 |
|
Systemic Inflammatory Response Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A MASP2 Y371D DD genotype predisposed to SIRS (OR 4·78, 1·06 to 21·59; P = 0·042) and septic shock (OR 2·53, 1·12 to 4·33; P = 0·003).
|
24227370 |
2013 |