Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nestin is detected in gliomas and glioblastomas, but not in normal brain tissue.
|
10800092 |
2000 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nestin is a member of intermediate filaments abundantly expressed in neural stem cells and glioblastomas.
|
15502861 |
2004 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association of glial to mesenchymal transition (GMT)-related molecular with ObR expression and VM formation in glioblastoma tissues indicated that ObR-positive glioblastoma cells with GMT phenotype might be more likely to constitute VM, and co-expression of ObR and CD133 or Nestin to constitute the channel impliated that ObR-positive glioblastoma cells displayed glioblastoma stem cells (GSC) properties.
|
28938545 |
2017 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Bioinformatics data have indicated that dopamine receptor (DRD) 2, DRD4, CD133 and Nestin were elevated in GBM clinical samples and correlated to Temozolomide (TMZ) resistance and increased aldehyde dehydrogenase (ALDH) activity (3.5-8.9%) as well as enhanced (2.1-2.4-fold) neurosphere formation efficiency in U87MG and D54MG GBM cell lines.
|
31561595 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD9 silencing in three CD133+ glioblastoma cell lines (NCH644, NCH421k and NCH660h) led to decreased cell proliferation, survival, invasion, and self-renewal ability, and altered expression of the stem-cell markers CD133, nestin and SOX2.
|
26573230 |
2016 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detailed information concerning the pattern of the nestin cytoskeleton in glioblastoma cell lines and especially the demonstration of nestin in the nucleus represent an important background for further studies of nestin re-expression in relationship to tumor malignancy and invasive potential.
|
16457706 |
2006 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, nestin is more specifically expressed in proliferating small-sized tumor vessels in glioblastoma and gastric, colorectal, and prostate cancers than are other tumor vessel markers.
|
21274370 |
2011 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, a glioblastoma-specific suicide gene, pEpo-NI2-SV-TK, was delivered into the intracranial glioblastoma model using reducible poly(oligo-d-arginines) (rPOA). pEpo-NI2-SV-TK has the erythropoietin (Epo) enhancer and the nestin intron 2 (NI2) for glioblastoma specific gene expression.
|
26178805 |
2015 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NG2 was frequently co-expressed with nestin and vimentin but rarely with CD133 and the NG2 positive tumour cells harboured genetic aberrations typical for GBM.
|
21863242 |
2011 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NG34 expresses the human <i>GADD34</i> gene under transcriptional control of a cellular Nestin gene promoter/enhancer element, whose expression occurs selectively in GBM.
|
29511029 |
2018 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of nestin in glioblastoma cells increased cell growth, sphere formation, and cell invasion.
|
25527454 |
2015 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological blockade with SR48692 or lentivirus mediated knockdown of NTSR1 efficiently reduced the sphere-forming ability and expression of stem cell markers such as nestin and Sox2 in GSCs isolated from glioblastoma cell line and glioblastoma tissues.
|
25200966 |
2014 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells.
|
28418837 |
2017 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Six initial and recurrent tumor pairs after bevacizumab (Bev) treatment were compared with GBMs from nine patients resected under neoadjuvant Bev treatment with regard to histological characteristics; MVD; MIB-1 index; and expression of vascular endothelial growth factor (VEGF) and its receptors, hypoxia markers (hypoxia-inducible factor 1 alpha, carbonic anhydrase 9), and nestin as a marker of glioma stem-like cells.
|
29262608 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data provides the first evidence that cell surface Nestin may serve as a promising GSC marker for the isolation and characterization of heterogeneous GSCs in glioblastomas.
|
23524267 |
2013 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TGF-alpha differentially regulates GFAP, vimentin, and nestin gene expression in U-373 MG glioblastoma cells: correlation with cell shape and motility.
|
10640425 |
2000 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to test whether prolactin changes gene expression and protein levels of nestin and microtubule-associated protein 2 (MAP2) in neuroblastoma (SK-N-SH) and glioblastoma (U-87MG) cells.
|
25629269 |
2014 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of FAT1, EMT (Snail/LOX/Vimentin/N-cad), stemness (SOX2/OCT4/Nestin/REST) and hypoxia markers (HIF-1α/VEGF/PGK1/CA9) was upregulated in ≥39% of GBM tumors (n = 31) with significant positive correlation (p ≤ 0.05) of the expression of FAT1 with LOX/Vimentin/SOX2/HIF-1α/PGK1/VEGF/CA9.
|
28994107 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that nestin plays a crucial role in development of glioblastoma and may potentially be targeted for treatment of the disease.
|
20669222 |
2011 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using a previously described culturing condition that selectively promotes the growth of brain tumor initiating cells, which express the stem cell markers nestin and SOX-2, we characterize the expression of α-amino-3-hydroxy-5-methyl-4-isozolepropionic acid (AMPA)-type glutamate receptor subunits in brain tumor initiating cells derived from glioblastomas.
|
23110111 |
2012 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also demonstrate that Tlx transcripts are overexpressed in human primary glioblastomas in which Tlx expression is restricted to a subpopulation of nestin-positive perivascular tumor cells.
|
20360385 |
2010 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We highlight the importance of Sox11 expression as a favourable prognosticator in glioblastomas. c-Met/nestin/IDH1-R132H expression phenotypes recapitulate the molecular subgroups of malignant glioma.
|
23619925 |
2013 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We provide evidence that sorafenib has a selective action on glioblastoma stem cells, causing enrichment of cultures in differentiated cells, downregulation of the expression of stemness markers required to maintain malignancy (nestin, Olig2 and Sox2) and reducing cell clonogenic ability in vitro and tumorigenic potential in vivo.
|
23324350 |
2013 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report here a novel targeted TMZ delivery strategy using a potent homing moiety, nestin, tagged to a polymeric nanocomposite to target glioblastoma.
|
28731079 |
2017 |