|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin was highly expressed in proliferating endothelial cells and nascent blood vessels in the growing tumor.
|
16500746 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin as a novel therapeutic target for pancreatic cancer via tumor angiogenesis.
|
22246533 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin-positive tumor cells were detected in all of the examined osteosarcomas using both immunohistochemistry and immunofluorescence, although the proportion of undoubtedly positive neoplastic cells varied in individual samples from a few nestin-positive tumor cells to diffuse nestin positivity.
|
22344865 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression in tumor cells was immunohistochemically studied in 30 patients with resected LCNEC, and its associations with clinicopathologic parameters including the Ki-67 labeling index (LI) and TTF-1 expression were evaluated.
|
22572237 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin may be an important marker of melanocytic neoplasms.
|
23417116 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression occurs in approximately one third of pancreatic ductal adenocarcinoma (PDAC), and its expression strongly correlates with tumor staging and metastasis.
|
23552743 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression was also studied immunohistochemically in surgically resected SCLC primary tumors and metastatic SCLC tumors obtained from autopsy cases.
|
23706418 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nestin immunoreactivity significantly correlated with not only tumor size and lymph node metastasis in NSCLC, but also poor survival in surgical patients with AD.
|
24481417 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression significantly correlated with overall tumor grade, lymph node, distant metastasis, and stage.
|
26945442 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nestin expression was found to be significantly associated with the unfavorable outcomes of differentiation degree (OR: 2.47; 95 % CI 1.61-3.79; P < 0.001), lymphatic metastasis (OR: 2.45; 95 % CI 1.41-4.25; P = 0.001), TNM stage (OR: 1.73; 95 % CI 1.07-2.79; P = 0.025) and tumor size (OR: 2.68; 95 % CI 1.20-5.98; P = 0.016), but not associated with gender, age, smoking status and NSCLC subtypes.
|
27099933 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Ablation of TAA dramatically suppresses Nestin expression and blocks tumor growth.
|
28986380 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although a variety of molecules, for example, VEGF, ETS-1 or nestin have been implicated in tumour angiogenesis, the molecular mechanisms of vessel formation are not fully characterized.
|
18212735 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Altogether, these results suggest that GFAP-δ and nestin could be clinically relevant markers associated with tumor invasiveness in cerebral astrocytomas.
|
25178519 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors.
|
29778085 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CD133 and nestin were detected in all 10 tumor tissue samples and in all 5 cell lines; however, the frequency of CD133+, Nes+, and CD133+/Nes+ cells, as well as the intensity of fluorescence varied in individual samples or cell lines.
|
22156015 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinically, nestin-negative tumors did not exhibit dissemination, while all tumors that exhibited dissemination also strongly expressed nestin protein.
|
18092184 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conditional expression of SCCRO using a replication-competent ASLV long terminal repeat with splice acceptor/nestin-(tumor virus-A) tv-a model system was not sufficient to induce tumor formation in a wild-type genetic background, but tumors formed with increasing frequency and decreasing latency in facilitated background containing Ink4a deletion alone or in combination with PTEN loss.
|
20563250 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Conversely, knockdown of nestin expression led to significant inhibition of tumor cell proliferation, decreased colony forming ability, and cell cycle G1 arrest.
|
24498263 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Detailed information concerning the pattern of the nestin cytoskeleton in glioblastoma cell lines and especially the demonstration of nestin in the nucleus represent an important background for further studies of nestin re-expression in relationship to tumor malignancy and invasive potential.
|
16457706 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
FOXA1 was a significant predictor of favorable outcome in primary breast cancer, while Nestin expression is preferentially found in triple-negative tumors with increased rate of nodal metastases, and reduced survival.
|
30819139 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, nestin and Sox-2 immunoreactivity was significantly associated with tumour cell proliferation and nestin expression was independently associated with poor patient survival.
|
21323603 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, compared with control cells, nestin short hairpin RNA (shRNA)-transfected glioblastoma cells exhibited reduced sphere formation, decreased expression of NANOG, N-cadherin, CD133, and Oct-4, and decreased tumor size in vivo.
|
25527454 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms.
|
22297445 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, many tumors were negative for nestin immunostaining, while nestin immunostaining was invariably detected in tumor endothelium regardless of glioma malignancy grades or brain tumor types.
|
11896213 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the exact mechanism by which nestin contributes to tumor malignancy remains poorly understood.
|
26434586 |
2016 |