|
Liver carcinoma
|
0.540 |
AlteredExpression
|
disease |
BEFREE |
IQGAP1 expression was higher in primary HCC (122/150, 81.3%) than matched adjacent tissues (30/150, 20%, p<0.001), whereas IQGAP2 was lower (31/150, 20.7% as compared to 112/150, 74.7%, P<0.001).
|
24998570 |
2014 |
|
Liver carcinoma
|
0.540 |
Biomarker
|
disease |
BEFREE |
Collectively, these results indicate that the Iqgap2 knockout mouse model closely recapitulates human HCC at the molecular level and supports its further application for the study of this disease.
|
23951254 |
2013 |
|
Liver carcinoma
|
0.540 |
Biomarker
|
disease |
MGD |
Collectively, these results indicate that the Iqgap2 knockout mouse model closely recapitulates human HCC at the molecular level and supports its further application for the study of this disease.
|
23951254 |
2013 |
|
Liver carcinoma
|
0.540 |
Biomarker
|
disease |
BEFREE |
Loss of IQGAP2 contributes to the tumorigenesis of hepatocellular carcinoma and gastric cancer.
|
22406297 |
2012 |
|
Liver carcinoma
|
0.540 |
Biomarker
|
disease |
CTD_human |
Similarly, immunohistochemical staining of 82 HCC samples showed that IQGAP2 protein expression was reduced in 64/82 (78.0%), while IQGAP1 was present in 69/82 (84.1%).
|
20977743 |
2010 |
|
Liver carcinoma
|
0.540 |
AlteredExpression
|
disease |
BEFREE |
In the current study we extend these findings, and investigate IQGAP1 and IQGAP2 expression in human HCC.
|
20977743 |
2010 |
|
Brain Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
|
27935819 |
2017 |
|
Malignant neoplasm of brain
|
0.300 |
Biomarker
|
disease |
CTD_human |
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
|
27935819 |
2017 |
|
Benign neoplasm of brain, unspecified
|
0.300 |
Biomarker
|
disease |
CTD_human |
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
|
27935819 |
2017 |
|
Brain Tumor, Primary
|
0.300 |
Biomarker
|
disease |
CTD_human |
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
|
27935819 |
2017 |
|
Recurrent Brain Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
|
27935819 |
2017 |
|
Primary malignant neoplasm of brain
|
0.300 |
Biomarker
|
disease |
CTD_human |
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
|
27935819 |
2017 |
|
Neoplasms, Intracranial
|
0.300 |
Biomarker
|
group |
CTD_human |
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
|
27935819 |
2017 |
|
Malignant neoplasm of liver
|
0.210 |
Biomarker
|
disease |
MGD |
Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
|
23951254 |
2013 |
|
Malignant neoplasm of liver
|
0.210 |
Biomarker
|
disease |
BEFREE |
Immunostaining of IQGAP1 and IQGAP2 may aid in the diagnosis of HCC, and their pharmacologic modulation may represent a novel therapeutic strategy for the treatment of liver cancer.
|
20977743 |
2010 |
|
Liver neoplasms
|
0.200 |
Biomarker
|
group |
MGD |
We also demonstrated that Iqgap2(-/-) hepatic tumors shared genetic signatures with HCC tumors from patients with advanced disease as evidenced by a 78% mouse-to-human microarray data set concordance rate with 117 out of 151 identified ortholog genes having similar expression profiles across the two species.
|
23951254 |
2013 |
|
Hepatoblastoma
|
0.200 |
Biomarker
|
disease |
MGD |
Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
|
23951254 |
2013 |
|
Hepatoblastoma Caused By Somatic Mutation
|
0.200 |
Biomarker
|
disease |
MGD |
Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
|
23951254 |
2013 |
|
hearing impairment
|
0.110 |
GeneticVariation
|
phenotype |
BEFREE |
The IQGAP2 tagSNP rs457717 was genotyped in accordance with the different ARHI phenotypes.
|
26187738 |
2016 |
|
hearing impairment
|
0.110 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association study for age-related hearing impairment in the Saami.
|
20068591 |
2010 |
|
hearing impairment
|
0.110 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study for age-related hearing impairment in the Saami.
|
20068591 |
2010 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of paliperidone efficacy.
|
27846195 |
2017 |
|
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of unique venous thromboembolism-susceptibility variants in African-Americans.
|
28203683 |
2017 |
|
Platelet Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |