Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease BEFREE In this review we focus on the roles of the calcium (Ca<sup>2+</sup>), sodium (Na<sup>+</sup>), potassium (K<sup>+</sup>), chloride (Cl<sup>-</sup>) and zinc (Zn<sup>2+</sup>) transporters in GI cancer, with a special emphasis on the roles of the KCNQ1 K<sup>+</sup> channel and CFTR Cl<sup>-</sup> channel in colorectal cancer (CRC). 31636470 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 AlteredExpression disease BEFREE Finally we analyzed expression of CFTR in early stage human CRC patients stratified by risk of recurrence and found that loss of expression of CFTR was significantly associated with poor disease-free survival. 26751771 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 Biomarker disease CTD_human The role of ABC transporters in progression and clinical outcome of colorectal cancer. 22294766 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.330 GeneticVariation disease BEFREE The CFTR 5T polymorphism was identified in 31 of 334 (9.3%) patients of sporadic pancreatic cancer, in 5 of 43 (11.6%) patients with familial pancreatic cancer and in 10 of 112 (8.9%) controls with colorectal cancer. 14688470 2004