Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In CF airways, the lack of CFTR and increased ENaC activity lead to ASL/mucus dehydration that causes mucus obstruction, neutrophilic infiltration, and chronic bacterial infection.
|
30028216 |
2018 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Loss-of-function mutations to the CFTR gene cause dehydrated mucus on the apical side of epithelial cells and increase the susceptibility of bacterial infection, especially in the airway and pulmonary tissues.
|
28805732 |
2017 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Briefly, RAW cells were treated with cigarette smoke extract (CSE), chloroquine (autophagy inhibitor), TFEB-shRNA, CFTR(inh)-172, and/or fisetin prior to bacterial infection for functional analysis.
|
29445254 |
2017 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Alteration in CFTR leads to thick airway mucus and bacterial infection.
|
28187947 |
2017 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
This article highlights major advances in our understanding of how CFTR dysfunction causes chronic mucus obstruction, neutrophilic inflammation and bacterial infection in CF airways.
|
24925916 |
2014 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Cystic fibrosis (CF) is caused by the loss of the cystic fibrosis transmembrane conductance regulator (CFTR) function and results in a respiratory phenotype that is characterized by dehydrated mucus and bacterial infections that affect CF patients throughout their lives.
|
22492740 |
2012 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Neutralizing anti-HMGB1 monoclonal antibody (mAb) conferred significant protection against P. aeruginosa-induced neutrophil recruitment, lung injury and bacterial infection in both CFTR(-/-) and wild-type mice.
|
22314397 |
2012 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In cystic fibrosis (CF), the absence of functional cystic fibrosis transmembrane conductance regulator (CFTR) translates into chronic bacterial infection, excessive inflammation, tissue damage, impaired lung function and eventual death.
|
20460375 |
2010 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In Cystic Fibrosis (CF), the absence of functional Cystic Fibrosis Transmembrane conductance Regulator (CFTR) translates into chronic bacterial infection, excessive inflammation, tissue damage, impaired lung function and eventual death.
|
19931506 |
2010 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Cystic fibrosis (CF), a disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, is characterized by chronic bacterial infections and inflammation in the lung.
|
20489160 |
2010 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The silencing of CFTR by CFTR RNAi in S9 cells significantly decreased ASMase activity after bacterial infection as compared with controls.
|
19168701 |
2009 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, a defect in CFTR function could cause abnormal mucus secretion leading to persistent bacterial infection and inflammation of the airways.
|
11845302 |
2001 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, we conclude that the presence of a mutated CFTR does not per se lead to an exaggerated inflammatory response of CF surface epithelial cells in the absence or presence of a bacterial infection.
|
10751364 |
2000 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data demonstrate that in utero, cftr expression influenced the development and function of cells involved in the primary host defense against bacterial infection in the lung.
|
9851885 |
1998 |