Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 Biomarker disease BEFREE Owing to similarities between chronic bronchitis and the autosomal-recessive disease Cystic Fibrosis (CF), a significant body of research addresses the hypothesis that dysfunctional CF Transmembrane Conductance Regulator (CFTR) is implicated in the pathogenesis of COPD. 31477092 2019
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 Biomarker disease BEFREE We, therefore, tested the hypothesis that CS exerts direct effects on the CFTR protein, which could impair airway hydration, leading to the mucus stasis characteristic of both cystic fibrosis and CB. 21990373 2012
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 Biomarker disease BEFREE We suggest that acquired CFTR deficiency may contribute to the physiopathology of cigarette-induced diseases such as chronic bronchitis. 16497995 2006
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 GeneticVariation disease BEFREE Comparison of clinical features of ACS showed that only a family history of chronic sinusitis (P <.01) or chronic bronchitis (P <.02) and the presence of diffuse bronchiectasis (P <.0001) or serous otitis media (P <.0001) were significantly more frequent in PCD patients than in patients carrying CFTR gene mutations or those without PCD or CFTR gene mutations. 15126740 2004
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 GeneticVariation disease BEFREE The ability to detect CFTR mutations has led to the recognition of its association with a variety of conditions, including chronic bronchitis, sinusitis with nasal polyps, pancreatitis, and, in men, infertility. 10503135 1999
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 GeneticVariation disease BEFREE In order to determine the possible role of the cystic fibrosis transmembrane regulator (CFTR) gene in pulmonary diseases not due to cystic fibrosis, a complete screening of the CFTR gene was performed in 120 Italian patients with disseminated bronchiectasis of unknown cause (DBE), chronic bronchitis (CB), pulmonary emphysema (E), lung cancer (LC), sarcoidosis (S) and other forms of pulmonary disease. 9921909 1998
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 GeneticVariation disease BEFREE Common CFTR mutations are not likely to predispose to chronic bronchitis in northern Germany. 7532152 1995
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic
0.170 Biomarker disease HPO