CFTR, CF transmembrane conductance regulator, 1080

N. diseases: 476; N. variants: 673
Disease: Influenza ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021400
Disease: Influenza
Influenza 		0.040 Biomarker disease BEFREE This review summarizes our present knowledge of how influenza virus infections alter airway and alveolar epithelial cell CFTR and ENaC function in vivo and in vitro and the role of these changes in influenza pathogenesis. 28775098 2017
CUI: C0021400
Disease: Influenza
Influenza 		0.040 Biomarker disease BEFREE We demonstrate that H5N1 HA attachment inhibits cAMP-dependent CFTR Cl(-) channels via JAK3-mediated adenylyl cyclase (AC) suppression, which reduces cAMP production. 25587856 2015
CUI: C0021400
Disease: Influenza
Influenza 		0.040 Biomarker disease BEFREE These results highlight CFTR damage, leading to early degradation as an important contributing factor to influenza infection-associated ion transport defects. 25795456 2015
CUI: C0021400
Disease: Influenza
Influenza 		0.040 AlteredExpression disease BEFREE The purpose of this study was to determine the contribution of this effect to influenza pathogenesis in mice with reduced CFTR activity. 23749967 2013