CFTR, CF transmembrane conductance regulator, 1080

N. diseases: 476; N. variants: 673
Disease: Acute leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.020 Biomarker disease BEFREE Our previous studies have demonstrated that a previously unrecognized role of CFTR in hematopoiesis and acute leukemia. 31541940 2019
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.020 AlteredExpression disease BEFREE In conclusion, our results showed CFTR was highly expressed in Ph+ acute leukemia, which protected and maintained the continuous activation of BCR-ABL and the canonical Wnt/β-catenin signaling pathway by decreasing PP2A phosphatase activity. 28445932 2017