Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.030 GeneticVariation disease BEFREE These findings identify an enhanced sensitivity of CFBE41o- cells expressing F508del CFTR to RSV infection, replication and monolayer disruption independent of the cellular immune response, and provide a novel mechanism by which cystic fibrosis airway epithelia are susceptible to RSV-dependent injury. 24056672 2013
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.030 Biomarker disease BEFREE To test whether the large 4.5-kb CFTR gene could be expressed by a recombinant RSV and whether infectious virus could be used to deliver CFTR to ciliated airway epithelium derived from CF patients, we inserted the CFTR gene into four sites in a recombinant green fluorescent protein-expressing RSV (rgRSV) genome to generate virus expressing four different levels of CFTR protein. 20504917 2010
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
0.030 Biomarker disease BEFREE These findings add to our understanding of individual RSV susceptibility and strongly support a modifier role for CFTR in RSV infection, a significant cause of respiratory morbidity in infants with cystic fibrosis. 20015999 2010