Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our results demonstrate for the first time that NEU3 contributes to the radioresistance features of U87MG cells, bringing to evidence a novel rand peculiar role of the enzyme in cancer biology.
|
30466783 |
2019 |
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Our results demonstrate for the first time that NEU3 contributes to the radioresistance features of U87MG cells, bringing to evidence a novel rand peculiar role of the enzyme in cancer biology.
|
30466783 |
2019 |
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We found NEU1 and NEU3 to be up regulated, while NEU4 was down regulated in most cancer types.
|
29278877 |
2018 |
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We found NEU1 and NEU3 to be up regulated, while NEU4 was down regulated in most cancer types.
|
29278877 |
2018 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The plasma membrane-associated sialidase NEU3 is involved in the fine-tuning of sialic acid-containing glycans directly on the cell surface and plays relevant roles in important biological phenomena such as cell differentiation, molecular recognition, and cancer transformation.
|
29039925 |
2017 |
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The plasma membrane-associated sialidase NEU3 is involved in the fine-tuning of sialic acid-containing glycans directly on the cell surface and plays relevant roles in important biological phenomena such as cell differentiation, molecular recognition, and cancer transformation.
|
29039925 |
2017 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Therefore, our data identify NEU3 as a key regulator of the β1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in RCC malignancy.
|
23139422 |
2012 |
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Therefore, our data identify NEU3 as a key regulator of the β1 integrin-recycling pathway and FAK/AKT signaling and demonstrate its crucial role in RCC malignancy.
|
23139422 |
2012 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
NEU3 is indeed closely related to malignancy and thus may be a potential target for cancer diagnosis and therapy.
|
18023981 |
2008 |
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
NEU3 is indeed closely related to malignancy and thus may be a potential target for cancer diagnosis and therapy.
|
18023981 |
2008 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
NEU3 may thus be an essential gene for cancer cell survival and siRNAs targeting this protein could have utility for gene-based therapy of human cancers.
|
17334392 |
2007 |
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
NEU3 may thus be an essential gene for cancer cell survival and siRNAs targeting this protein could have utility for gene-based therapy of human cancers.
|
17334392 |
2007 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
To date, no information concerning the possible role played by NEU3 in relation to tumor radioresistance is available.
|
30466783 |
2019 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
While NEU1, NEU2 and NEU4 have been observed to oppose malignant phenotypes, the membrane-bound sialidase NEU3 was revealed to promote cancer progression.
|
29278877 |
2018 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
When NEU3 was stably transfected with or without EGFR, it was associated with significant increases in clonogenic growth, clonogenicity on soft agar and in vivo tumor growth in nude mice either with or without the receptor overexpression in the presence of EGF, compared with the levels in their vector controls.
|
25803810 |
2015 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These findings identify NEU3 as an essential participant in tumorigenesis through the EGFR/Src signaling pathway and a potential target for inhibiting EGFR-mediated tumor progression.
|
25803810 |
2015 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
NEU3 siRNA introduction caused reduction of cell growth of an androgen-independent PC-3 cells in culture and of transplanted tumors in nude mice.
|
21681193 |
2012 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that NEU3 regulates tumor progression through AR signaling, and thus be a potential tool for diagnosis and therapy of androgen-independent prostate cancer.
|
21681193 |
2012 |
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here we show that overexpression of NEU3 in glioblastoma U87MG cells activates PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation.
|
30466783 |
2019 |
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here we show that overexpression of NEU3 in glioblastoma U87MG cells activates PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation.
|
30466783 |
2019 |
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here we show that overexpression of NEU3 in glioblastoma U87MG cells activates PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation.
|
30466783 |
2019 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The plasma membrane-associated sialidase NEU3 is known to play important roles in different physiological and pathophysiological processes such as proliferation, cellular differentiation and tumorigenesis.
|
30466783 |
2019 |
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here we show that overexpression of NEU3 in glioblastoma U87MG cells activates PI3K/Akt signaling pathway resulting in an increased radioresistance capacity and in an improved efficiency of double strand DNA-repair mechanisms after irradiation.
|
30466783 |
2019 |
Tay-Sachs Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.
|
28974375 |
2018 |
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Sialidase NEU3 was found to exert a great influence on cell invasion in regulation of calpain activity and focal adhesion disassembly and consequent invasive potential of glioblastoma cells.
|
28760640 |
2017 |