Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Regulation of heparanase gene expression by estrogen in breast cancer.
|
14695198 |
2003 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Varieties of experiments indicated that heparanase mRNA is overexpressed in human tumors, including breast cancer, gastrointestinal tumors, and esophageal carcinomas.
|
27804885 |
2017 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
SIGNIFICANCE: This study reveals the role of heparanase in promoting obesity-associated breast cancer and provides a mechanistically informed approach to uncouple obesity and breast cancer in a rapidly growing population of obese patients.
|
31481501 |
2019 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunocytochemistry analysis demonstrated that heparanase was expressed in lymphocytes of breast cancer PBMC.
|
17603633 |
2007 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that targeting heparanase might improve treatments for breast cancer patients.
|
28388549 |
2017 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, knockdown of heparanase or inhibition of its activity with JG6, a heparanase inhibitor, was sufficient to block the formation of cell clusters and suppress breast cancer metastasis.
|
29417941 |
2018 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study implies that overexpression of EcSOD is a promising strategy to enhance the efficacy of heparin/LMWH by inhibiting heparanase as a novel treatment for breast cancer.
|
19602586 |
2009 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A highly significant correlation (P<0.0001) between estrogen receptor (ER) positivity and heparanase overexpression was found in breast cancer.
|
17634531 |
2007 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Also, we estimated the diagnostic usefulness of the heparanase concentration for disease recurrence prediction in breast cancer cases.
|
31566192 |
2019 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression.
|
26084486 |
2015 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.
|
30543095 |
2019 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cDNA of the enzyme responsible for cleaving HS chains from proteoglycans, HPSE1, was cloned in the pEGFP-N1 plasmid and transfected into a breast cancer cell lineage.
|
24083474 |
2013 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that heparanase expression increases during the progression of breast cancer into invasive cancer, and that this change is accompanied by increased COX-2 expression.
|
16391819 |
2006 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Silencing of heparanase by siRNA inhibits tumor metastasis and angiogenesis of human breast cancer in vitro and in vivo.
|
17457040 |
2007 |
Malignant neoplasm of breast
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
We detected levels of heparanase expression and DNA methylation patterns of its promoter in breast cancer cell lines (MCF-7 and MDA-MB-435) and clinical tissues, respectively.
|
24632672 |
2014 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Heparanase (HPR) is overexpressed in breast cancer but downregulated in differentiated normal tissue.
|
16271435 |
2006 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In contrast, the HPSE levels in breast cancer with lymph node metastasis were the highest.
|
23415719 |
2013 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggested that ELE may be a promising agent targeting heparanase in the treatment of breast cancer.
|
28560389 |
2017 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
4-HPR Is an Endoplasmic Reticulum Stress Aggravator and Sensitizes Breast Cancer Cells Resistant to TRAIL/Apo2L.
|
30061204 |
2018 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that HPSE-1 not only contributes to the invasive phenotype of melanoma cells, but also that the Ad-AS/hep-mediated inhibition of its enzymatic activity can be efficacious in the prevention and treatment of melanoma metastasis.
|
15799825 |
2005 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A multifactorial analysis using Cox's regression model revealed that β-catenin, lymphoid enhancer-binding protein-1, heparanase-1, and the TNM stage were all independent factors in malignant melanoma (risk ratios were 7.294, 5.550, 5.622, and 4.794; p-values were 0.007, 0.018, 0.018, and 0.029, respectively).
|
25343173 |
2015 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low metastatic murine T-lymphoma and melanoma cells transfected with the heparanase cDNA acquired a highly metastatic phenotype in vivo, reflected by a massive liver and lung colonization.
|
10395325 |
1999 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lentiviral miR30-based RNA interference against heparanase suppresses melanoma metastasis with lower liver and lung toxicity.
|
23847439 |
2013 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the relevance of the dual functions of HPSE to malignant melanoma in vitro, as well as in different mouse melanoma models based on the intradermal or intravenous injection of melanoma cells.
|
25745999 |
2015 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation.
|
22719918 |
2012 |