|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CEA level and Poorly differentiated histology of colon cancer was significantly correlated with high NLR (P = 0.005 and P = 0.048, respectively).
|
30941323 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impact of synchronized anti-PD-1 with Ad-CEA vaccination on inhibition of colon cancer growth.
|
31192764 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Secondly, ENST00000455974 showed a better sensitivity and specificity than CEA and CA19-9 in the diagnosis of pMMR CC by drawing the receiver operating characteristic (ROC) curve.
|
30473216 |
2019 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical value of a diagnostic score for colon cancer based on serum CEA, CA19-9, cytokeratin-1 and mucin-1.
|
29734875 |
2018 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, both piRNAs exhibited satisfactory diagnostic performance also in patients with stage I disease and enabled detection of colon cancer with higher sensitivity than currently used biomarkers CEA and CA19-9.
|
29976566 |
2018 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
CEA not only may improve staging of colon cancer but may also help guide additional therapy.
|
28290141 |
2017 |
|
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ROC curve showed that miR-125a-3p abundant level may predict colon cancer with an area of under the curve (AUC) of 68.5%, in comparison to that of CEA at 83.6%.
|
28646161 |
2017 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A loss of antitumor therapeutic activity of CEA DNA vaccines is associated with the lack of tumor cells' antigen presentation to Ag-specific CTLs in a colon cancer model.
|
25449428 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, when therapeutic scaffolds were implanted into CEA-positive human colon cancer xenograft-bearing mice and human T lymphocytes were subsequently transferred, circulating alphaCEA/alphaCD3 diabody activated T cells and promoted tumor cell lysis.
|
19096041 |
2009 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
CK20 and CEA are significantly more frequently detected in colon cancer patients than in healthy controls and can serve as markers.
|
19645077 |
2009 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro evaluation of cancer-specific NF-kappaB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines.
|
17687334 |
2007 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, CEA-specific T-cell precursors could be readily expanded by in vitro stimulation of peripheral blood mononuclear cell (PBMC) from colon cancer patients with altered CEA peptide.
|
17447064 |
2007 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
PBLs transduced by infection with a lentivirus/VSV pseudotyped vector were able to proliferate specifically in vitro on exposure to CEA-expressing cells and further they had a startling therapeutic effect in a mouse model of human colon cancer.
|
16507098 |
2006 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the systemic administration of AdCEAp/Rep was considered to be effective on multiple liver metastases of CEA-positive colon cancer in a xenograft model.
|
15564136 |
2004 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to selectively reverse MDR in malignant tissue without disrupting the function of normal colonocytes, a retroviral vector (pCEAMR) containing anti-mdr1 ribozyme coupled to the carcino-embryonic-antigen (CEA) promoter was constructed and introduced into resistant colon-cancer cells (SW1116R) that produce CEA and into control resistant cells (HeLaK) that do not produce CEA.
|
10399951 |
1999 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of pCEA correlates well with the CEA production by the specific cell line offering a potential tissue-specific targeting strategy for colon cancer gene therapy.
|
9645743 |
1998 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CEA mRNA did not appear to correlate with metastasis because its expression in the primary colon cancers with metastases (Dukes' stage D tumor) was not always increased.
|
1290028 |
1992 |