Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Univariate logistic regression analysis showed that CEA (OR 1.056, 95% CI 1.007-1.107, p = 0.02) was the only preoperative predictor for occult metastases.
|
31186205 |
2019 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A decreased overall survival was significantly associated with peritoneal involvement (HR 1.944; p = 0.003), ascites (HR 2.055; p = 0.034), synchronous presentation (HR 1.679; p = 0.034) and increased serum CEA levels (HR 1.380; p = 0.010), but not with age > 50 (HR 0.946; p = 0.743), menopausal status (HR 1.565; p = 0.204), gastric origin (HR 1.600; p = 0.201), size > 5 cm (HR 1.292; p = 0.119), size > 10 cm (HR 0.925; p = 0.714), bilateral ovarian involvement (HR 1.113; p = 0.347), non-peritoneal extaovarian metastases (HR 1.648; p = 0.237), liver metastases (HR 1.118, p = 0.555), predominant signet ring cell morphology (HR 1.322; p = 0.208) and levels of CA125 (HR 0.933; p = 0.828) and CA19.9 (HR 0.996; p = 0.992).
|
31542818 |
2019 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High platelet count (H-PC) was found in 32%, and it was associated with a higher rate of palliative surgery (p < 0.001), extra-hepatic metastases (p < 0.001), bilobar liver disease (p = 0.007), presence of more than three metastases (p = 0.005), biggest metastasis larger than 5 cm (p < 0.001), and CEA level higher than 200 ng/mL (p = 0.035).
|
30937817 |
2019 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Several pretreatment factors, including lower carcinoembryonic antigen (CEA; ≤20 ng/mL), lower aspartate transaminase (AST; ≤40 IU/L), neutrophil-lymphocyte ratio (NLR) <5, and absence of extrahepatic disease at baseline were associated with significantly improved OS after RE, compared with high CEA (>20 ng/mL), high AST (>40 IU/L), NLR ≥5, and extrahepatic metastases (P values of <.001, <.001, .0001, and .04, respectively).
|
29754852 |
2018 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
CEA and CA125 were associated with tumor metastasis and therapeutic response.
|
28267695 |
2017 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, deguelin-treated tumors showed decreased the tumor metastasis related genes such as CD44, MMP2 and MMP9 at protein and mRNA levels and the content of CEA, SCC, NSE, CYFAR21-1.
|
26884827 |
2015 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Postoperative follow-up found that all patients with high levels of CEA mRNA and serum CEA and the related proteins had liver, lung, pelvis, or other distant metastases.
|
24783267 |
2014 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In patients with distant metastases and ascites the levels of CEA, CA19-9, and CA24-2 were higher than in patients without these conditions (p=0.003, p=0.001, p=0.001, p=0.016, p= 0.011, and p=0.030, respectively).
|
23787496 |
2013 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether 1 of 2 vaccines based on dendritic cells (DCs) and poxvectors encoding CEA (carcinoembryonic antigen) and MUC1 (PANVAC) would lengthen survival in patients with resected metastases of colorectal cancer (CRC).
|
23657083 |
2013 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CEA levels of HNPCC tumors increased significantly under occurrence of metastases with mean values of 170.3 +/- 343 (p < 0.02).
|
16122885 |
2005 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
We, in the present study, constructed a self-replicable adenovirus in which E1A is driven by a CEA promoter and E1B-55K is deleted from the E1B region (AdCEAp/Rep) and examined its effects on multiple metastases of a human colon cancer cell in a mouse xenograft model.
|
15564136 |
2004 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Endometrial carcinomas and their metastases were generally positive for ER (86%), PR (93%) and VIM (100%) but rarely positive for CEA (14%) and HPV (0%).
|
15010819 |
2004 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
These results show that both mammaglobin RT-PCR and CEA RT-PCR are useful tools for the detection of breast cancer metastases in axillary lymph nodes.
|
11592097 |
2001 |
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Hitherto anti-CEA monoclonal antibodies (MAbs), normally of mouse origin, have been used primarily for clinical diagnosis of colorectal cancer, either as a tumor marker in serum to monitor tumor recurrence, or latterly as a means to localize in vivo CEA-bearing tumors, and metastases in patients.
|
1431347 |
1992 |
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CEA mRNA did not appear to correlate with metastasis because its expression in the primary colon cancers with metastases (Dukes' stage D tumor) was not always increased.
|
1290028 |
1992 |