|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Mean Corpuscular Volume (result)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here, we review the possible genetic, molecular, and functional role of RAB10 in AD and potential therapeutic approaches to target RAB10.
|
30643396 |
2019 |
|
Alzheimer's Disease
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
These findings indicate that Rab10 phosphorylation could be responsible for aberrations in the vesicle trafficking observed in AD leading to neurodegeneration.
|
29562525 |
2018 |
|
Alzheimer's Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.
|
29329552 |
2018 |
|
Alzheimer's Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we replicated this association in an independent series of unrelated individuals (p value = 0.028, odds ratio = 0.69) and used a gene-based test to confirm a role for RAB10 variants in modifying AD risk (p value = 0.002).
|
29183403 |
2017 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recent work established that multiple Rab GTPases are physiological substrates of LRRK2, with Rab10 in particular emerging as a human substrate whose site-specific phosphorylation mirrors hyperactive LRRK2 lesions associated with PD.
|
29305429 |
2018 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
RAB10 is associated with Parkinson's disease (PD).
|
29310658 |
2018 |
|
Parkinson Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Interestingly, Rab10 is a key substrate of leucine-rich repeat kinase 2 (LRRK2), a serine/threonine protein kinase genetically associated with the second most common neurodegenerative disease Parkinson's disease.
|
29562525 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
The levels of LINC00152, microRNA-107 (miR-107) and Ras-related protein Rab-10 (Rab10) were measured in ESCC tissues and cells using qRT-PCR.
|
31802892 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Collectively, miR‑378a‑3p may act as a tumor‑suppressor in ESCC cells through negatively regulating Rab10.
|
29693138 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
The silencing of Rab10 revealed antitumor effects in ESCC cell lines, and the expression of miR‑378a‑3p was negatively correlated with that of Rab10 in ESCC.
|
29693138 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
RAB10 overexpression promotes tumor growth and indicates poor prognosis of hepatocellular carcinoma.
|
28460436 |
2017 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To be concluded, PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10, which may be contributory to find new targets to treat glioma.
|
31812014 |
2020 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this study, we found that LINC00152 modulated Rab10 to promote cell proliferation, migration and invasion in ESCC by sponging miR-107.
|
31802892 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Interestingly, Rab10 is a key substrate of leucine-rich repeat kinase 2 (LRRK2), a serine/threonine protein kinase genetically associated with the second most common neurodegenerative disease Parkinson's disease.
|
29562525 |
2018 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Rab3D is a member of the ras-related GTP-binding protein Rab family and was found up-regulated in several types of cancer.
|
28472755 |
2017 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr<sup>db/db</sup> type 2 diabetic mice.
|
28793909 |
2017 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Experimentally, we demonstrated that knockdown of RAB10 resulted in a significant decrease in Aβ42 (p value = 0.0003) and in the Aβ42/Aβ40 ratio (p value = 0.0001) in neuroblastoma cells.
|
29183403 |
2017 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Experimentally, we demonstrated that knockdown of RAB10 resulted in a significant decrease in Aβ42 (p value = 0.0003) and in the Aβ42/Aβ40 ratio (p value = 0.0001) in neuroblastoma cells.
|
29183403 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Rab3D is a member of the ras-related GTP-binding protein Rab family and was found up-regulated in several types of cancer.
|
28472755 |
2017 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, RAB10 knockdown suppressed HCC growth in nude mice.
|
28460436 |
2017 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Experimentally, we demonstrated that knockdown of RAB10 resulted in a significant decrease in Aβ42 (p value = 0.0003) and in the Aβ42/Aβ40 ratio (p value = 0.0001) in neuroblastoma cells.
|
29183403 |
2017 |