UTS2, urotensin 2, 10911

N. diseases: 115; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.030 Biomarker disease BEFREE 1 Urotensin-II (U-II) is among the most potent mammalian vasoconstrictors identified and may play a role in the aetiology of essential hypertension. 12770952 2003
CUI: C0206667
Disease: Adrenal Cortical Adenoma
Adrenal Cortical Adenoma 		0.010 Biomarker disease BEFREE Urotensin II-like immunoreactivity was detected in one of eight adrenocortical adenomas, two of four adrenocortical carcinomas, one of six pheochromocytomas, and one of five neuroblastomas by radioimmunoassay, but not in normal portions of adrenal glands (detection limit; 0.2pmol/g wet weight). 12668216 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE U-II is also a neuropeptide and may play a role in tumour development. 15883758 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.580 Biomarker group CTD_human Urotensin-II (U-II) receptors are widely distributed in the central nervous system.Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. 16160878 2005
CUI: C0428977
Disease: Bradycardia
Bradycardia 		0.300 Biomarker phenotype CTD_human Urotensin-II (U-II) receptors are widely distributed in the central nervous system.Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. 16160878 2005
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.040 Biomarker disease BEFREE UII may also play a role in renal disease, being elevated in the circulation or urine of patients with renal failure and in experimental models of cardiovascular disease such as the spontaneously hypertensive rat. 16807543 2006
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.100 Biomarker group BEFREE UII may also play a role in renal disease, being elevated in the circulation or urine of patients with renal failure and in experimental models of cardiovascular disease such as the spontaneously hypertensive rat. 16807543 2006
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.100 Biomarker group LHGDN UII may also play a role in renal disease, being elevated in the circulation or urine of patients with renal failure and in experimental models of cardiovascular disease such as the spontaneously hypertensive rat. 16807543 2006
CUI: C0009777
Disease: Conn Adenoma
Conn Adenoma 		0.010 AlteredExpression disease BEFREE Urotensin II was more expressed in pheochromocytoma than in aldosterone-producing adenoma tissue; the opposite was seen for the urotensin II receptor expression. 19001524 2009
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma 		0.030 Biomarker disease BEFREE Urotensin II is a putative mediator of the effects of the adrenal medulla and pheochromocytoma on the adrenocortical zona glomerulosa. 19001524 2009
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma 		0.030 Biomarker disease BEFREE Urotensin II is a putative mediator of the effects of the adrenal medulla and pheochromocytoma on the adrenocortical zona glomerulosa. 19001524 2009
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.100 AlteredExpression group BEFREE Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis. 19111831 2009
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 AlteredExpression disease BEFREE Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis. 19111831 2009
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 AlteredExpression disease BEFREE Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis. 19111831 2009
CUI: C0018801
Disease: Heart failure
Heart failure 		0.060 Biomarker disease BEFREE Urotensin II (UII) and its receptor UT are involved in control of the cardiovascular system and are implicated in heart failure. 19258379 2009
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.060 Biomarker disease BEFREE Urotensin II (UII) and its receptor UT are involved in control of the cardiovascular system and are implicated in heart failure. 19258379 2009
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.010 Biomarker disease BEFREE Urotensin II (UII) and its receptor (UT or GPR14) are involved in liver fibrosis and portal hypertension. 20428787 2010
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 AlteredExpression disease BEFREE UII and UT gene expression were quantified in liver biopsy samples from patients with hepatitis-B-virus-associated cirrhosis and portal hypertension, and from normal controls by using quantitative real-time PCR. 20428787 2010
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.030 AlteredExpression disease BEFREE UII and UT gene expression were quantified in liver biopsy samples from patients with hepatitis-B-virus-associated cirrhosis and portal hypertension, and from normal controls by using quantitative real-time PCR. 20428787 2010
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.020 AlteredExpression disease BEFREE UII and UT gene expression were quantified in liver biopsy samples from patients with hepatitis-B-virus-associated cirrhosis and portal hypertension, and from normal controls by using quantitative real-time PCR. 20428787 2010
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension 		0.010 AlteredExpression disease BEFREE UII and UT gene expression were quantified in liver biopsy samples from patients with hepatitis-B-virus-associated cirrhosis and portal hypertension, and from normal controls by using quantitative real-time PCR. 20428787 2010
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.010 GeneticVariation group BEFREE Urotensin II (UTS-II) is predominantly a vasoactive peptide and Thr21Met polymorphism in UTS-II gene was proved to increasing in some autoimmune diseases. 23333481 2013
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis 		0.020 Biomarker disease BEFREE Urotensin II (U-II/UTS2) induces cardiac fibrosis by increasing fibroblast collagen synthesis and increased U-II plasma levels have been reported in patients with atrial fibrosis. 26811505 2016
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.220 Biomarker disease BEFREE Urotensin II (UII) and autophagy have been considered as important components in the pathogenesis of diabetic nephropathy. 27459313 2017
CUI: C0018801
Disease: Heart failure
Heart failure 		0.060 Biomarker disease BEFREE Urotensin II and its receptor are thought to be involved in various cardiovascular diseases such as heart failure, pulmonary hypertension and atherosclerosis. 28163023 2017