UTS2, urotensin 2, 10911

N. diseases: 115; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.050 AlteredExpression disease BEFREE Silymarin ameliorates expression of urotensin II (U-II) and its receptor (UTR) and attenuates toxic oxidative stress in the heart of rats with type 2 diabetes. 29494961 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.050 Biomarker disease BEFREE Overall, our present study provides the first evidence that both UTS2 and UTS2R genes regulate skeletal muscle fat accumulation and fatty acid metabolism, thus indicating their potential pathological functions related to obesity and T2DM in humans. 18463714 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation disease BEFREE It can inhibit glucose-induced insulin secretion, and genetic variants in urotensin II gene are associated with insulin resistance and type 2 diabetes. 17610998 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation disease BEFREE These results strongly suggest that subjects with S89N in the UTS2 gene are more insulin-resistant and thus more susceptible to type 2 diabetes mellitus development. 15476949 2004
Diabetes Mellitus, Non-Insulin-Dependent
0.050 GeneticVariation disease BEFREE These results strongly suggest that the S89N polymorphism in the UTS2 gene is associated with the development of Type 2 diabetes, via insulin sensitivity, in Japanese subjects. 12830381 2003