UTS2, urotensin 2, 10911

N. diseases: 115; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 GeneticVariation group BEFREE Ser89Asn (S89N) polymorphisms of the UTS2 gene were associated with hypertension in a Chinese female population. 27941008 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group BEFREE Urotensin II and its receptor are thought to be involved in various cardiovascular diseases such as heart failure, pulmonary hypertension and atherosclerosis. 28163023 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group BEFREE Intracerebroventricular (ICV) injection of UII in these vertebrates provokes hypertension and tachycardia, suggesting that the cardio-inhibitory baroreflex response is impaired. 28239335 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 AlteredExpression group BEFREE Chronic treatment with nimesulide or NS-398 (5 mg/kg/day) for 3 weeks lowered high blood pressure and cardiac hypertrophy with decreased expression levels of cardiac hypertrophy markers [atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP)], Ang type 1 receptor, urotensin II, and urotensin II receptor in 2K1C rats. 25846103 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group BEFREE The involvement of urotensin II, a vasoactive peptide acting via the G protein-coupled urotensin II receptor, in arterial hypertension remains contentious. 19001524 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group BEFREE Iontophoresis of U-II in healthy volunteers produces vasodilation (of the forearm) while in patients with heart failure or hypertension a constriction is observed. 17680191 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 GeneticVariation group BEFREE We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. 16597476 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group CTD_human Urotensin-II (U-II) receptors are widely distributed in the central nervous system.Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. 16160878 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group LHGDN Our findings raise the possibility that urotensin II may have an aetiological role in hypertension and its complications. 15201550 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group RGD These results suggest that central urotensin II may play a role in the pathogenesis of hypertension in SHR. 14621188 2003