|
Sentinel node (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In multivariate analysis, hypermethylation of GSTP1 and/or RAR-beta2 was significantly associated with patients having macroscopic SLN metastasis compared with those with microscopic or no sentinel node metastasis (odds ratio, 4.59; 95% confidence interval, 2.02-10.4; P < 0.001).
|
15788661 |
2005 |
|
Attention deficit hyperactivity disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Promyelocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells.
|
15896339 |
2005 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Disturbed expression of retinoic acid (RA) receptors (RAR/RXR) contributes to the pathogenesis and tumor progression of epithelial carcinomas.
|
15080786 |
2004 |
|
Von Hippel-Lindau Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In comparison with the normal mucosa of the non-cancer patients, the following 14 genes displayed no tumor associated changes: breast cancer 1, early onset (BRCA1), cadherin 1, type 1, E-cadherin (epithelial) (CDH1), death-associated protein kinase 1 (DAPK1), DNA (cytosine-5-)-methyltransferase 1 (DNMT1), melanoma antigen, family A, 1 (directs expression of antigen MZ2-E) (MAGEA1), tumor suppressor candidate 3 (N33), cyclin-dependent kinase inhibitor 1A (p21, Cip1) (p21(WAF1)), cyclin-dependent kinase inhibitor 1B (p27, Kip1) (p27(KIP1)), phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN), retinoic acid receptor, beta (RAR- , Ras association (RalGDS/AF-6) domain family 1 C (RASSF1C), secreted frizzled-related protein 1 (SFRP1), tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) (TIMP3), and von Hippel-Lindau syndrome (VHL).
|
15526363 |
2004 |
|
Nephroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The rest changed greatly in the methylation pattern in colorectal cancer (CRC): cyclin A1 (cyclin a1) (100%, 65/65), caudal type homeobox transcription factor 1 (CDX1) (100%, 65/65), RAR- (85%, 55/65), myogenic factor 3 (MYOD1) (69%, 45/65), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (p15(INK4b)) (68%, 44/65), prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (COX2) (72%, 47/65), cadherin 13, H-cadherin (heart) (CDH13) (65%, 42/65), CAAX box 1 (CXX1) (58%, 38/65), tumor protein p73 (p73) (63%, 41/65) and Wilms tumor 1 (WT1) (58%, 38/65).
|
15526363 |
2004 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Disturbed expression of retinoic acid (RA) receptors (RAR/RXR) contributes to the pathogenesis and tumor progression of epithelial carcinomas.
|
15080786 |
2004 |
|
Follicular thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All-trans-RA and RAR-selective synthetic retinoids stimulated activity and mRNA expression of the thyroid differentiation marker 5'DI in the follicular thyroid carcinoma cell line FTC-133.
|
15080786 |
2004 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
RAR mRNA expression levels are significantly different in Barrett's tissues compared with normal esophagus tissues, and these levels are significantly different in Barrett's dysplasia and adenocarcinoma tissues compared with nondysplastic tissues.
|
11231454 |
2001 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PML appears to be involved in multiple functions, including apoptosis and transcriptional activation by RAR, whereas PML-RARalpha blocks these functions of PML.
|
11430826 |
2001 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study evaluated the effects of all-trans (high affinity ligand for both RAR and RXR receptors) and 9-cis retinoic acid (binds only with RXR receptors) on E6-E7 transcription, cell proliferation, cell cycle distribution, and p53 expression in CaSki cells, a cell line derived from cervical carcinoma containing 600 copies of the HPV-16 genome.
|
9718082 |
1998 |
|
Refractory cancer
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia.
|
9657734 |
1998 |
|
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The NPM sequences contained in the shorter NPM-RAR cDNA are identical to the NPM sequences contained in the NPM-ALK fusion gene expressed in t(2;5) lymphomas.
|
8562957 |
1996 |
|
Fatty Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that the expression of genes for RAR and RXR isoforms and catalase were not altered by ethanol in the fatty liver.
|
7837930 |
1995 |
|
Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that the expression of genes for RAR and RXR isoforms and catalase were not altered by ethanol in the fatty liver.
|
7837930 |
1995 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirteen pts had Acute Promyelocytic Leukemia (APL) with rearrangements of the RAR-a and PML genes, 8 BCR rearranged (BCR+)/Ph+ Chronic Myeloid Leukemia (CML) and 3 BCR+/Ph+ Acute Lymphoid Leukemia (ALL).
|
8152281 |
1994 |
|
Myeloid Leukemia, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thirteen pts had Acute Promyelocytic Leukemia (APL) with rearrangements of the RAR-a and PML genes, 8 BCR rearranged (BCR+)/Ph+ Chronic Myeloid Leukemia (CML) and 3 BCR+/Ph+ Acute Lymphoid Leukemia (ALL).
|
8152281 |
1994 |
|
Teratocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The RAR expression in F9 cells was slightly down-regulated in charcoal-stripped culture medium and returned to normal level after retinoic acid treatment.
|
8136307 |
1994 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirteen pts had Acute Promyelocytic Leukemia (APL) with rearrangements of the RAR-a and PML genes, 8 BCR rearranged (BCR+)/Ph+ Chronic Myeloid Leukemia (CML) and 3 BCR+/Ph+ Acute Lymphoid Leukemia (ALL).
|
8152281 |
1994 |
|
Depressive Symptoms
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These RAR characteristics correlated with greater fatigue (Spearman r = 0.36) but not depression symptom severity.
|
30024782 |
2018 |
|
Depressive Symptoms
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The following sleep-wake measures were associated with greater depression symptom severity (absolute Spearman's correlations ranged from 0.23 to 0.32): more time awake after sleep onset (WASO), higher RAR middle level (mesor), relatively shorter active periods (alpha), earlier evening settling time (down-mesor) and less steep RARs (beta).
|
28488270 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Promoter hypomethylation of RAR-related orphan receptor α 1 is correlated with unfavorable clinicopathological features in patients with colorectal cancer.
|
27301432 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrated that the expression level of Rab40b was significantly correlated with GC invasion classification (P < 0.01), lymph node metastasis (P < 0.01), and pathological stage (P < 0.01).
|
25790780 |
2015 |
|
Leukemogenesis
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study identifies a novel mechanism through which NPM-RAR affects leukemogenesis.
|
25033841 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
FXR was expressed in 48 of 59 esophageal adenocarcinoma tissues (81.3%), and this overexpression was associated with higher tumor grade, larger tumor size, and lymph node metastasis; however, was inversely associated with retinoic acid receptor-β2 (RAR-β2 ) expression.
|
23280144 |
2013 |