Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
ACSVL3 expression knockdown using RNA interference, which decreased long-chain fatty acid activation, inhibited anchorage-dependent and anchorage-independent glioma cell growth by approximately 70% and approximately 90%, respectively.
|
19920185 |
2009 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
ACSVL3-depleted cells were less tumorigenic than control cells, and subcutaneous xenografts grew approximately 60% slower than control tumors.
|
19920185 |
2009 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
A link between ACSVL3 and cancer stem cell phenotype was further established by the findings that ACSVL3 expression was regulated by receptor tyrosine kinase pathways that support GBM stem cell self-renewal and tumor initiation, including EGFR and HGF/c-Met pathways.
|
24893952 |
2014 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
A link between ACSVL3 and cancer stem cell phenotype was further established by the findings that ACSVL3 expression was regulated by receptor tyrosine kinase pathways that support GBM stem cell self-renewal and tumor initiation, including EGFR and HGF/c-Met pathways.
|
24893952 |
2014 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Decreasing the growth rate of lung cancer cell lines did not change ACSVL3 expression.
|
23936004 |
2013 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Decreasing the growth rate of lung cancer cell lines did not change ACSVL3 expression.
|
23936004 |
2013 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Decreasing the growth rate of lung cancer cell lines did not change ACSVL3 expression.
|
23936004 |
2013 |
Malignant Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of the fatty acyl-CoA synthetase ACSVL3 was found to be markedly elevated in clinical malignant glioma specimens but nearly undetectable in normal glia.
|
19920185 |
2009 |
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, ACSVL3 knockdown reduced anchorage-independent neurosphere cell growth, neurosphere-forming capacity as well as self-renewal of these GBM stem cell enriched neurosphere cultures.
|
24893952 |
2014 |
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.
|
26548558 |
2015 |
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity.
|
24893952 |
2014 |
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity.
|
24893952 |
2014 |
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity.
|
24893952 |
2014 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The downregulation of Cav-1 and ACSVL3 suggested a reduction of tumor growth.
|
25015569 |
2014 |
Glioma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The lower fatty acyl pool may be mediated by the lower protein expression levels of long-chain acyl-CoA synthetase 1 (ACSL1), ACSL4, and very long-chain acyl-CoA synthetase 3 (ACSVL3) in IDH1 mutant glioma.
|
30596429 |
2019 |
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth.
|
25015569 |
2014 |
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth.
|
25015569 |
2014 |
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth.
|
25015569 |
2014 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth.
|
25015569 |
2014 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth.
|
25015569 |
2014 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
This study investigates the role of ACSVL3 in the maintenance of glioblastoma multiforme (GBM) stem cell self-renewal and the capacity of GBM stem cells to initiate tumor xenograft formation.
|
24893952 |
2014 |
Tumor Initiation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
To study the function of ACSVL3, we performed loss-of-function by using small interfering RNAs to target ACSVL3 and examined stem cell marker expression, neurosphere formation and tumor initiation properties.
|
24893952 |
2014 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We previously found that the fatty acyl-CoA synthetase VL3 (ACSVL3) is elevated in malignant brain tumor tissues and involved in tumorigenesis.
|
24893952 |
2014 |
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We previously reported that an enzyme of fatty acid metabolism, very long-chain acyl-CoA synthetase 3 (ACSVL3), is overexpressed in malignant glioma, and that depleting glioblastoma cells of ACSVL3 diminishes their malignant properties.
|
23936004 |
2013 |