|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
The RCC-1-defined antigen detects a novel breast cancer associated antigen.
|
1699883 |
1990 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The RCC-1-defined antigen detects a novel breast cancer associated antigen.
|
1699883 |
1990 |
|
X-linked retinitis pigmentosa
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A gene (RPGR) with homology to the RCC1 guanine nucleotide exchange factor is mutated in X-linked retinitis pigmentosa (RP3).
|
8673101 |
1996 |
|
RETINITIS PIGMENTOSA 3
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A gene (RPGR) with homology to the RCC1 guanine nucleotide exchange factor is mutated in X-linked retinitis pigmentosa (RP3).
|
8673101 |
1996 |
|
X-linked retinitis pigmentosa
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1.
|
8817343 |
1996 |
|
RETINITIS PIGMENTOSA 3
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1.
|
8817343 |
1996 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Among 23 mice given injections of RCC-1 cells containing this YAC, 16 (70%) remained tumor free for at least 6 months, whereas tumor formation occurred after a median of 6 weeks in control mice given injections of either RCC-1 parental cells or a revertant cell line (in which the YAC had lost all human sequences) or RCC-1 parental cells containing other, unrelated YACs.
|
10491433 |
1999 |
|
Congenital deafness
|
0.010 |
Biomarker
|
disease |
BEFREE |
DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness.
|
10571079 |
1999 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function.
|
11956218 |
2002 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although CHC1-L is not the obvious candidate given its only known homology, to RCC1, a guanine nucleotide exchange factor for the Ras-related GTPase Ran, the frequent significant decrease observed in its expression in prostate cancer associated with the difference in frequency of CHC1-L variant isoforms between normal and neoplastic prostate tissues places it in a pivotal role or possibly adjacent to a gene that has that role in prostate cancer evolution.
|
12115502 |
2002 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although CHC1-L is not the obvious candidate given its only known homology, to RCC1, a guanine nucleotide exchange factor for the Ras-related GTPase Ran, the frequent significant decrease observed in its expression in prostate cancer associated with the difference in frequency of CHC1-L variant isoforms between normal and neoplastic prostate tissues places it in a pivotal role or possibly adjacent to a gene that has that role in prostate cancer evolution.
|
12115502 |
2002 |
|
Retinitis Pigmentosa
|
0.020 |
Biomarker
|
disease |
LHGDN |
Novel deletion spanning RCC1-like domain of RPGR in Japanese X-linked retinitis pigmentosa family.
|
16052169 |
2005 |
|
Muscle Spasticity
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The mutation, which falls within the RCC1 domain, was identified in a 34-year-old patient with typical signs of JPLS such as ascending generalized and severe spasticity involving the limbs and the bulbar region, dysphagia, limb atrophy, preserved cognition and sensation.
|
16670179 |
2006 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells.
|
19075597 |
2008 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Cell cycle regulatory protein 5 (Cdk5) is a novel downstream target of ERK in carboplatin induced death of breast cancer cells.
|
19075597 |
2008 |
|
X-linked retinitis pigmentosa
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The cilia-expressed gene RPGR (retinitis pigmentosa GTPase regulator) is mutated in patients with X-linked retinitis pigmentosa (XLRP) and encodes multiple protein isoforms with a common N-terminal domain homologous to regulator of chromosome condensation 1 (RCC1), a guanine nucleotide exchange factor (GEF) for Ran GTPase.
|
20631154 |
2010 |
|
Retinitis Pigmentosa
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The cilia-expressed gene RPGR (retinitis pigmentosa GTPase regulator) is mutated in patients with X-linked retinitis pigmentosa (XLRP) and encodes multiple protein isoforms with a common N-terminal domain homologous to regulator of chromosome condensation 1 (RCC1), a guanine nucleotide exchange factor (GEF) for Ran GTPase.
|
20631154 |
2010 |
|
Polycystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8.
|
22899815 |
2012 |
|
Nephronophthisis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8.
|
22899815 |
2012 |
|
Polycystic Kidney - body part
|
0.010 |
Biomarker
|
disease |
BEFREE |
A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8.
|
22899815 |
2012 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
In this study, we found that estrogen receptor β (ERβ) was more highly expressed in RCC cell lines (A498, RCC-1, 786-O, ACHN, and Caki-1) than in breast cancer cell lines (MCF-7 and HBL-100); however, no androgen receptor (AR) or estrogen receptor α (ERα) could be detected by western blot.
|
23460808 |
2013 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In this study, we found that estrogen receptor β (ERβ) was more highly expressed in RCC cell lines (A498, RCC-1, 786-O, ACHN, and Caki-1) than in breast cancer cell lines (MCF-7 and HBL-100); however, no androgen receptor (AR) or estrogen receptor α (ERα) could be detected by western blot.
|
23460808 |
2013 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that estrogen receptor β (ERβ) was more highly expressed in RCC cell lines (A498, RCC-1, 786-O, ACHN, and Caki-1) than in breast cancer cell lines (MCF-7 and HBL-100); however, no androgen receptor (AR) or estrogen receptor α (ERα) could be detected by western blot.
|
23460808 |
2013 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that estrogen receptor β (ERβ) was more highly expressed in RCC cell lines (A498, RCC-1, 786-O, ACHN, and Caki-1) than in breast cancer cell lines (MCF-7 and HBL-100); however, no androgen receptor (AR) or estrogen receptor α (ERα) could be detected by western blot.
|
23460808 |
2013 |
|
Embryonal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In vitro differentiation of the NTERA2 EC cell line resulted in significantly reduced expression of both fusion transcripts involving RCC1 and the ETV6 transcript variant, indicating that they are markers of pluripotency in a malignant setting.
|
26659575 |
2016 |