|
Carcinoma breast stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with untreated HER2-negative MBC were randomized (1:1) to receive 28-day cycles of paclitaxel 90 mg/m(2) IV (days 1, 8, and 15) and bevacizumab 10 mg/kg IV (days 1, 15) with either everolimus 10 mg (Arm 1) or placebo (Arm 2) daily.
|
26456573 |
2015 |
|
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ADRM1 was upregulated in both untreated AL samples and leukemia cell lines.
|
25896055 |
2015 |
|
Metastatic human epidermal growth factor 2 positive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
This phase I/II dose-escalation study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics, and efficacy of the pan-class I phosphoinositide 3-kinase inhibitor pilaralisib in combination with trastuzumab (Arm 1) or trastuzumab plus paclitaxel (Arm 2) in patients with HER2-positive metastatic breast cancer.
|
25537644 |
2015 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Protocol-indicated surgery was performed in 6 women, identifying two ovarian malignancies and yielding a surgical PPV in both arms combined of 33% (95% confidence interval: 4%-78%), 25% in Arm 1 and 50% in Arm 2.
|
24789859 |
2014 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
ADRM1 gene amplification is a candidate driver for metastatic gastric cancers.
|
24968865 |
2014 |
|
Epithelial ovarian cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We conducted a randomized controlled pilot trial to estimate surgical PPV of a "2 of 3 tests positive" screening rule, and to compare use of HE4 as a first-line (Arm 1) versus a second-line (Arm 2) screen, in women at high and elevated risk for epithelial ovarian cancer (EOC) at five study sites.
|
24789859 |
2014 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, ADRM1 knockdown inhibited MHCC97-H cell proliferation and induced cell apoptosis, and the migration and invasion of MHCC97-H cells were significantly repressed.
|
22576803 |
2012 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that there is a clear functional connection between ADRM1 and NF-κB in hepatocarcinogenesis, despite the precise mechanisms through which the two work together still being unknown.
|
22576803 |
2012 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Regiment with combined application of Adrm1 RNA interference and chemotherapy may emerge as a novel therapeutic strategy for Adrm1 overexpressed colorectal cancer.
|
19148532 |
2009 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Adrm1 mRNA was overexpressed in 46.2% (18/39) colorectal cancer tissues compared to their matched normal mucosa and significantly correlated with lymph node metastasis of colorectal cancer (P=0.037).
|
19148532 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Regiment with combined application of Adrm1 RNA interference and chemotherapy may emerge as a novel therapeutic strategy for Adrm1 overexpressed colorectal cancer.
|
19148532 |
2009 |
|
T-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, gp110(high) viruses infected the carcinoma cell line HeLa and the T cell lymphoma cell line Molt-4, both previously thought to be refractory to EBV infection.
|
12409611 |
2002 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plasma from 16 patients with MS, eight with OND and 72 healthy donors were tested for antibodies by ELISA to HHV-6 early (p41/38) and late (gp110) proteins.
|
9987758 |
1998 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The Epstein-Barr virus (EBV) glycoprotein gp110 has substantial amino acid homology to gB of herpes simplex virus but localizes differently within infected cells and is essentially undetectable in virions.
|
8627735 |
1996 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Although knowledge has accumulated about GP110-CD4 interaction, viral penetration into human CD4+ lymphocytes remains unclear, in spite of the fact that all studies on HIV infection were performed on cell-transformed lineages, or on human polyclonal CD4+ cells.
|
2121340 |
1990 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using the combined Sanger sequencing and TaqMan junction assays, unique and common expressions of spliced variants including enzyme regulators (ARHGEF2, SERPINH1), chromatin modifiers (DEK, CDK9, RBBP7), RNA-binding proteins (SRSF3, RBM27, MATR3, YBX1), and receptors (ADRM1, CD44v8-10, vitamin D receptor, ROR1) were determined in HCC tumors.
|
30637779 |
2019 |
|
ovarian neoplasm
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, we sought to determine if RPN13 is available as a target in precursors of ovarian/fallopian tube cancer as well as all advanced cases, and the impact of increased ADRM1 gene copy number on sensitivity of ovarian cancer to RA190.
|
28784174 |
2017 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Adhesion regulating molecule 1 (ADRM1), a 19S proteasome cap-associated protein, and nuclear factor kappa B (NF-κB), a protein transcription factor controlling DNA transcription, may play an important role in tumorigenesis.
|
22576803 |
2012 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We found that both mRNA and protein levels of ADRM1 were increased in HCC tissues and that this increase in ADRM1 expression was parallel to the metastatic potential of HCC cell lines.
|
22576803 |
2012 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Recently, we showed that among 20q13-amplified genes in ovarian cancer, ADRM1 overexpression was the most highly correlated with amplification and was significantly upregulated with respect to stage, recurrence, and metastasis.
|
21432940 |
2011 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these data suggested that Adrm1 is potentially oncogenic and may play an important role in colon tumorigenesis.
|
19148532 |
2009 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Of the 19 candidate genes in this subset, ADRM1 overexpression was the most highly correlated with amplification, was amplified in a higher percentage of tumors than ZNF217 and TPD54, and was significantly upregulated with respect to stage, recurrence and metastasis.
|
18615678 |
2008 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
|
ovarian neoplasm
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We also found that higher mRNA ADRM1 expression was significantly correlated with poor survival in patients with breast cancer.
|
31669266 |
2019 |