Epstein-Barr Virus Infections
|
0.040 |
Biomarker
|
group |
BEFREE |
HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection.
|
15288002 |
2004 |
Epstein-Barr Virus Infections
|
0.040 |
Biomarker
|
group |
BEFREE |
In addition, gp110(high) viruses infected the carcinoma cell line HeLa and the T cell lymphoma cell line Molt-4, both previously thought to be refractory to EBV infection.
|
12409611 |
2002 |
Epstein-Barr Virus Infections
|
0.040 |
Biomarker
|
group |
BEFREE |
To investigate whether gp110, like gB, is essential for EBV infection, a selectable marker was inserted within the gp110 reading frame, BALF4, and the resulting null mutant EBV stain, B95-110HYG, was recovered in lymphoblastoid cell lines (LCLs).
|
8627735 |
1996 |
Epstein-Barr Virus Infections
|
0.040 |
Biomarker
|
group |
BEFREE |
Humans with serologic evidence of Epstein-Barr virus infection had serum antibodies to gp110 and peripheral blood T cells that recognized peptides from gp110 and HLA-Dw4 encompassing the QKRAA determinant.
|
2472638 |
1989 |
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We also found that higher mRNA ADRM1 expression was significantly correlated with poor survival in patients with breast cancer.
|
31669266 |
2019 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Our findings revealed that ADRM1 mRNA levels were significantly associated with estrogen receptor (ER) status, progesterone receptor status, tumor size, lymph node status, histologic grade, and molecular subtypes.
|
31669266 |
2019 |
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We also found that higher mRNA ADRM1 expression was significantly correlated with poor survival in patients with breast cancer.
|
31669266 |
2019 |
Malignant neoplasm of ovary
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here, we sought to determine if RPN13 is available as a target in precursors of ovarian/fallopian tube cancer as well as all advanced cases, and the impact of increased ADRM1 gene copy number on sensitivity of ovarian cancer to RA190.
|
28784174 |
2017 |
Carcinoma, Ovarian Epithelial
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here, we sought to determine if RPN13 is available as a target in precursors of ovarian/fallopian tube cancer as well as all advanced cases, and the impact of increased ADRM1 gene copy number on sensitivity of ovarian cancer to RA190.
|
28784174 |
2017 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Postmenopausal women (N = 14) with resectable, HR+, human epidermal growth factor receptor 2-negative (HER2-) early BC were randomized 1:1:1 to receive 2.5 mg/day letrozole alone (Arm 1), or with 400 or 600 mg/day ribociclib (Arm 2 or 3).
|
27336726 |
2016 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Postmenopausal women (N = 14) with resectable, HR+, human epidermal growth factor receptor 2-negative (HER2-) early BC were randomized 1:1:1 to receive 2.5 mg/day letrozole alone (Arm 1), or with 400 or 600 mg/day ribociclib (Arm 2 or 3).
|
27336726 |
2016 |
Carcinoma, Ovarian Epithelial
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We conducted a randomized controlled pilot trial to estimate surgical PPV of a "2 of 3 tests positive" screening rule, and to compare use of HE4 as a first-line (Arm 1) versus a second-line (Arm 2) screen, in women at high and elevated risk for epithelial ovarian cancer (EOC) at five study sites.
|
24789859 |
2014 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Further research is necessary to determine whether targeting knockdown of ADRM1 in 20q13-amplified ovarian cancers results in growth inhibition and tumor suppression via downstream targets GIPC1 and RECK.
|
21432940 |
2011 |
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
Further research is necessary to determine whether targeting knockdown of ADRM1 in 20q13-amplified ovarian cancers results in growth inhibition and tumor suppression via downstream targets GIPC1 and RECK.
|
21432940 |
2011 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Of the 19 candidate genes in this subset, ADRM1 overexpression was the most highly correlated with amplification, was amplified in a higher percentage of tumors than ZNF217 and TPD54, and was significantly upregulated with respect to stage, recurrence and metastasis.
|
18615678 |
2008 |
Malignant neoplasm of ovary
|
0.030 |
Biomarker
|
disease |
BEFREE |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer.
|
18615678 |
2008 |
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cell-mediated responses to EBV replicative cycle proteins and to gp110 have been documented in joint fluid from RA patients.
|
17625943 |
2007 |
Rheumatoid Arthritis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection.
|
15288002 |
2004 |
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Northern blot analysis of human breast cancer cell lines revealed 3- to 5-fold elevated ARM-1 mRNA levels in metastatic as compared to non-metastatic cells.
|
10919708 |
1999 |
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Northern blot analysis of human breast cancer cell lines revealed 3- to 5-fold elevated ARM-1 mRNA levels in metastatic as compared to non-metastatic cells.
|
10919708 |
1999 |
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
An analysis of protein and DNA databases revealed that the Epstein-Barr virus glycoprotein gp110, which is encoded by the BALF4 open reading frame, contains the sequence QKRAAQRAA, which is highly homologous to the rheumatoid arthritis susceptibility determinant.
|
2472638 |
1989 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using the combined Sanger sequencing and TaqMan junction assays, unique and common expressions of spliced variants including enzyme regulators (ARHGEF2, SERPINH1), chromatin modifiers (DEK, CDK9, RBBP7), RNA-binding proteins (SRSF3, RBM27, MATR3, YBX1), and receptors (ADRM1, CD44v8-10, vitamin D receptor, ROR1) were determined in HCC tumors.
|
30637779 |
2019 |
ovarian neoplasm
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, we sought to determine if RPN13 is available as a target in precursors of ovarian/fallopian tube cancer as well as all advanced cases, and the impact of increased ADRM1 gene copy number on sensitivity of ovarian cancer to RA190.
|
28784174 |
2017 |
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Adhesion regulating molecule 1 (ADRM1), a 19S proteasome cap-associated protein, and nuclear factor kappa B (NF-κB), a protein transcription factor controlling DNA transcription, may play an important role in tumorigenesis.
|
22576803 |
2012 |