Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.030 GeneticVariation phenotype BEFREE The presence of risk allele at rs115160714 TopBP1 determined a higher incidence of nodal metastases (OR = 7.98, 95 % CI: 3.94-16.00, p = 0.001) and higher tumor grade (OR = 6.48, 95 % CI: 0.86-48.01, p = 0.03). 26503213 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.030 AlteredExpression phenotype BEFREE Functional analyses indicated that the expression TopBP1 and Claspin positively affects the survival of cancer cells and thus negatively the xenograft metastasis model animals in response to radiation. 25216549 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.030 Biomarker phenotype BEFREE There was no significant association between level and intracellular localization of TopBP1 protein in hereditary breast cancer and other clinicopathological parameters such as estrogen and progesterone receptors status, appearance of metastasis in the axillary lymph nodes and type of cancer. 22544570 2012