|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
BTN3A2 was shown to be the most abundant isoform in PDAC and was stress-regulated.
|
29296524 |
2017 |
|
Breast Carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Multivariate cox regression analysis revealed that BTN3A2 was an independently prognostic signature of TNBC, as well as weighted correlation network analysis suggested BTN3A2 was only correlated with TNBC, rather than other subtypes of BRCA.
|
31692043 |
2020 |
|
Breast Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
|
29915430 |
2018 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We have associated variants at 1p35.2 and 6p22.1 with gastric cancer risk, indicating a role for SPOCD1 and BTN3A2 in gastric carcinogenesis.
|
28246015 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
BTN3A2 expression in epithelial ovarian cancer is associated with higher tumor infiltrating T cells and a better prognosis.
|
22685580 |
2012 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
BTF4/BTNA3.2 and GCS as candidate mRNA prognostic markers in epithelial ovarian cancer.
|
18398031 |
2008 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
Consequently, CD277, and likely other butyrophilins and butyrophilin-like molecules, emerge as regular players in the orchestration of immunosuppressive networks in ovarian cancer, and therefore new targets for interventions to overcome immune evasion and boost anti-tumor immunity in cancer patients.
|
21113407 |
2010 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
However, immune infiltrations were highly correlated with BTN3A2 in triple-negative breast cancer (TNBC), compared with OV and other subtypes of BRCA.
|
31692043 |
2020 |
|
Child Development Disorders, Pervasive
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Corpuscular Hemoglobin Concentration Mean
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Seventy-five genetic loci influencing the human red blood cell.
|
23222517 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is important to note that these associations were independent of the HLA-DRB1-DQA1-DQB1 genes, as well as of associations observed at HLA-A, -B and -C. Taken together, our results identify PRSS16 and BTN3A2, two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for T1D.
|
19295542 |
2009 |
|
Epithelial ovarian cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
BTF4/BTNA3.2 and GCS as candidate mRNA prognostic markers in epithelial ovarian cancer.
|
18398031 |
2008 |
|
Epithelial ovarian cancer
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
BTN3A2 expression in epithelial ovarian cancer is associated with higher tumor infiltrating T cells and a better prognosis.
|
22685580 |
2012 |
|
Hepatitis C
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
BTN3A2 rs9104 was strongly associated with genotype 1 infection and the haplotype BTN3A3 rs13220495 CC+IL28B genotype CC was universal in patients with hepatitis C genotype 3a.
|
25928882 |
2016 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
BEFREE |
Multivariate cox regression analysis revealed that BTN3A2 was an independently prognostic signature of TNBC, as well as weighted correlation network analysis suggested BTN3A2 was only correlated with TNBC, rather than other subtypes of BRCA.
|
31692043 |
2020 |
|
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
CTD_human |
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
|
29915430 |
2018 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, immune infiltrations were highly correlated with BTN3A2 in triple-negative breast cancer (TNBC), compared with OV and other subtypes of BRCA.
|
31692043 |
2020 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Consequently, CD277, and likely other butyrophilins and butyrophilin-like molecules, emerge as regular players in the orchestration of immunosuppressive networks in ovarian cancer, and therefore new targets for interventions to overcome immune evasion and boost anti-tumor immunity in cancer patients.
|
21113407 |
2010 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have associated variants at 1p35.2 and 6p22.1 with gastric cancer risk, indicating a role for SPOCD1 and BTN3A2 in gastric carcinogenesis.
|
28246015 |
2017 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
γ9δ2T cells, which express Vγ9 and Vδ2 chains of the T cell receptor (TCR), mediate cancer immune surveillance by sensing early metabolic changes in malignant leukemic blast and not their healthy hematopoietic stem counterparts via the γ9δ2TCR targeting joined conformational and spatial changes of CD277 at the cell membrane (CD277J).
|
30871629 |
2019 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
|
29915430 |
2018 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
|
29915430 |
2018 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
|
29915430 |
2018 |