FOXN3, forkhead box N3, 1112

N. diseases: 40; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.020 AlteredExpression disease BEFREE We have previously shown that the hyperglycemia risk allele (A) increases FOXN3 expression in primary human hepatocytes; over-expression of human FOXN3 in zebrafish liver increases fasting blood glucose; and heterozygous deletion of the zebrafish ortholog <i>foxn3</i> decreases fasting blood glucose. 31543974 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.020 GeneticVariation disease BEFREE Recently, we reported that primary hepatocytes from rs8004664 hyperglycemia risk allele carriers have increased FOXN3 transcript and protein levels and liver-limited overexpression of human FOXN3, a transcriptional repressor that had not been implicated in metabolic regulation previously, increases fasting blood glucose in zebrafish. 29996093 2018