KIF3A, kinesin family member 3A, 11127

N. diseases: 64; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.440 GeneticVariation disease BEFREE The KIF3A rs12186803 risk allele interacted with food sensitization to increase asthma risk in children with eczema (P = 0.02). 30830718 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.440 GeneticVariation disease GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.440 GeneticVariation disease GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.440 GeneticVariation disease GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.440 Biomarker disease BEFREE This work aimed to investigate the role of KIF3A in epithelium apoptosis and bronchial inflammation in asthma. 29156524 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.440 Biomarker disease CTD_human The association between KIF3A rs7737031 and asthma was validated in 3 independent populations, further substantiating the validity of our gene selection approach. 21912604 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.440 GeneticVariation disease BEFREE The association between KIF3A rs7737031 and asthma was validated in 3 independent populations, further substantiating the validity of our gene selection approach. 21912604 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.440 GeneticVariation disease BEFREE Our findings suggest that the KIF3A gene and/or its polymorphisms might have a susceptibility effect on AIA, providing a new step toward controlling aspirin intolerance in asthmatics. 20922562 2011
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.300 Biomarker group CTD_human Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. 27793025 2016
CUI: C3179349
Disease: Gastrointestinal Stromal Sarcoma
Gastrointestinal Stromal Sarcoma 		0.300 Biomarker disease CTD_human Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. 27793025 2016
CUI: C0005941
Disease: Bone Diseases, Developmental
Bone Diseases, Developmental 		0.300 Biomarker group CTD_human Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. 17698054 2007
CUI: C0152427
Disease: Polydactyly
Polydactyly 		0.300 Biomarker disease CTD_human Here we demonstrate that conditional inactivation of the Kif3a subunit of the kinesin-2 intraflagellar transport motor in mesenchymal skeletal progenitor cells results in severe patterning defects in the craniofacial area, the formation of split sternum and the development of polydactyly. 17698054 2007
CUI: C0376634
Disease: Craniofacial Abnormalities
Craniofacial Abnormalities 		0.300 Biomarker group CTD_human Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. 17698054 2007
CUI: C0013393
Disease: Dysostoses
Dysostoses 		0.200 Biomarker disease MGD
CUI: C0085413
Disease: Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Autosomal Dominant 		0.200 Biomarker disease MGD
CUI: C3149841
Disease: POLYCYSTIC KIDNEY DISEASE 1
POLYCYSTIC KIDNEY DISEASE 1 		0.200 Biomarker disease MGD
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.130 Biomarker disease BEFREE Our study indicates that KIF3A and OVOL1 are involved in the development of AD in the Chinese pediatric population. 26127003 2015
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.130 GeneticVariation disease GWASCAT Meta-analysis identifies seven susceptibility loci involved in the atopic march. 26542096 2015
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.130 GeneticVariation disease GWASCAT Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. 26482879 2015
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.130 GeneticVariation disease BEFREE To verify the association, between AE and rs479844, rs2164983, and rs2897442, target for OVOLI (11q13), ACTL9 (19p13.2), and in KIF3A (5q31) genes in the Italian population. 23278845 2013
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.130 GeneticVariation disease BEFREE We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. 23042114 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.130 GeneticVariation disease GWASCAT Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. 22197932 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.130 GeneticVariation disease GWASDB Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. 22197932 2011
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.110 GeneticVariation disease GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.110 GeneticVariation disease GWASCAT Meta-analysis identifies seven susceptibility loci involved in the atopic march. 26542096 2015