|
Adrenal Gland Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An mRNA of approximately 2.3Kb was detected with the cDNA probes in human cell lines from MTC and lung cancers that were shown to produce CgA and in human pheochromocytoma and bovine adrenal medulla tissue.
|
3718511 |
1986 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma.
|
28948824 |
2017 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also screened members of families with MEN-2 or von Hippel-Lindau disease for pheochromocytoma by measuring plasma and urine catecholamines and plasma chromogranin A and by performing abdominal ultrasonography, CT and MRI, and metaiodobenzylguanidine scintigraphy.
|
8105382 |
1993 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Positive chromogranin A staining of the tumor cells confirmed a diagnosis of pheochromocytoma.
|
30078826 |
2018 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the immunostaining of CgA in the tumor cells showed peculiar dot-like staining located corresponding to Golgi complex in the perinuclear area, rather than the diffuse cytoplasmic staining usually observed in epinephrine- or norepinephrine-producing functional pheochromocytomas and paragangliomas.
|
27743246 |
2017 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We can conclude that plasma CGA concentration as determined by radioimmunometric assay (which is simple without the necessity of special laboratory equipment) is an effective marker of pheochromocytoma with association to malignity and tumor mass.
|
18271679 |
2008 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A retrospective study of SDHB and SDHD NIH patients' cohort, which included 41 patients with SDHB mutation-related PHEO/sPGL and 18 patients with either SDHD or SDHB mutation-related head and neck PGL (HNPGL) with both CgA and NMN measured at the time of diagnosis at NIH.
|
24467715 |
2014 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromogranin A in the Laboratory Diagnosis of Pheochromocytoma and Paraganglioma.
|
31027285 |
2019 |
|
Adrenal Gland Pheochromocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we therefore compared tumour and plasma levels of CGA in patients with phaeochromocytoma associated with the two syndromes.
|
18046660 |
2007 |
|
Adrenocortical carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Archival, formaldehyde-fixed, and paraffin-embedded material comprising 27 adrenocortical carcinomas (ACC, meeting Weiss' histologic criteria), 28 pheochromocytomas (PCC), and adjacent nontumorous tissue (13 glands) were analyzed by immunogold-silver staining for the expression of polysialic acid (poly Sia), cytokeratins (CK), synaptophysin (SYN), chromogranin A (CrgA), somatostatin (SOM), calcitonin (CT), and the "adrenocortical marker" D11.
|
7723281 |
1995 |
|
Adult Angiosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although a number of authors have noted aberrant expression of cytokeratins, CD30, CD117 and neuroendocrine markers (synaptophysin and chromogranin A) in AS, intense positive nuclear staining for S100 protein in neoplastic cells has not hitherto been observed.
|
28475514 |
2018 |
|
Adult atopic dermatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The change in salivary CgA per protein in patients with AD was correlated with their changes in SCORAD score (correlation coefficient, r = 0.596, P = 0.001) and objective SCORAD (r = 0.608, P < 0.001).
|
29500830 |
2018 |
|
Adult atopic dermatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The amount of salivary CgA per protein in patients with AD was correlated with their SCORAD score (r = 0.458, P < 0.001).
|
28406540 |
2017 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the effect of CgA secretion on neoplastic morphogenesis and progression, we have transfected mouse RMA lymphoma and TS/A adenocarcinoma cells with the cDNA encoding human CgA and selected several CgA-positive (secreting) and CgA-negative (nonsecreting) clones.
|
11830555 |
2002 |
|
ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subcellular distribution of phosphatase and tensin (PTEN), chromogranin A (CHGA), and alpha thalassemia/mental retardation syndrome X-linked (ATRX) were significantly different by WHO classifications (p ≤ 0.05).
|
23361940 |
2013 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
For chromogranin A, two of three peptides had significantly lowered AD concentrations (p<0.01).
|
29028155 |
2018 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we highlight the role of DAMPs, including amyloid β (Aβ), high-mobility group box 1 (HMGB1), the S100 family proteins, chromogranin A, and nucleic acids, in the innate-immune activation during the course of Alzheimer disease (AD), the most frequent neurodegenerative disorder.
|
28049142 |
2017 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
LHGDN |
Different chromogranin immunoreactivity between prion and a-beta amyloid plaque.
|
12692477 |
2003 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that CgA is not a promising clinical biomarker for ALS.
|
29609078 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
If confirmed on a larger group of patients, CgA may also become useful in the diagnosis of sporadic ALS.
|
28185258 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS.
|
20807312 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
0.040 |
Biomarker
|
disease |
LHGDN |
Eight cases of ALS and seven control cases were studied with semiquantitative immunocytochemistry for chromogranin A, chromogranin B and secretogranin II that are soluble constituents of large dense core vesicles, synaptophysin as a membrane protein of small synaptic vesicles and superoxide dismutase 1.
|
18721831 |
2009 |
|
Angina, Unstable
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The plasma catestatin levels in patients with STEMI and UAP were lower than the levels seen in patients without CAD.
|
27681934 |
2018 |
|
Anxiety
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis.
|
28406540 |
2017 |
|
Anxiety Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis.
|
28406540 |
2017 |