|
21-hydroxylase deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The study involved a monogenic analysis of CYP21A2 in patients (375 nonclassical 21OHD [NC21OHD] children; 306 hyperandrogenic 21OHD carriers, n = 306) and a polygenic association study (CAPN10-UCSNP44, PON1-108, TNFR2-M196R, IGF2-ApaI and IRS1-G972R polymorphisms) of 170 hyperandrogenic carriers plus 277 family members (control groups).
|
19039234 |
2009 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
CAPN10 association with CIMT was replicated, further supporting its role as a common genetic determinant of diabetes and atherosclerosis in Hispanics.
|
19193380 |
2009 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
We sought to determine whether CAPN10 influences subclinical atherosclerosis.
|
15793266 |
2005 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study.
|
11756346 |
2002 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
We sought to determine whether CAPN10 influences subclinical atherosclerosis.
|
15793266 |
2005 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
LHGDN |
We sought to determine whether CAPN10 influences subclinical atherosclerosis.
|
15793266 |
2005 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
CAPN10 association with CIMT was replicated, further supporting its role as a common genetic determinant of diabetes and atherosclerosis in Hispanics.
|
19193380 |
2009 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study.
|
11756346 |
2002 |
|
Carcinoma of larynx
|
0.020 |
Biomarker
|
disease |
BEFREE |
We analyzed CAPN10 UCSNP-44, UCSNP-43, UCSNP-19, and UCSNP-63 allelic distributions in 199 patients with unrelated laryngeal cancer.
|
20848425 |
2011 |
|
Carcinoma of larynx
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to examine the contribution of CAPN10 alleles to the development of laryngeal cancer.
|
17382509 |
2008 |
|
Cardiovascular Diseases
|
0.040 |
GeneticVariation
|
group |
BEFREE |
However, due to its association with androgen excess in phenotype A, CAPN 10 gene polymorphism UCSNP-43 could be used as a genetic marker for CVD in young PCOS women.
|
26376770 |
2015 |
|
Cardiovascular Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
As its homologue CAPN10, CAPN5 seems to influence traits related to increased risk for cardiovascular diseases.
|
17227582 |
2007 |
|
Cardiovascular Diseases
|
0.040 |
GeneticVariation
|
group |
BEFREE |
The calpain 10 gene (CAPN10) has been associated with type 2 diabetes (T2DM), a complex metabolic disorder with increased risk of cardiovascular disease.
|
18698425 |
2008 |
|
Cardiovascular Diseases
|
0.040 |
GeneticVariation
|
group |
LHGDN |
Genetic links between diabetes mellitus and coronary atherosclerosis.
|
18241614 |
2007 |
|
Cerebral Small Vessel Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The SNP43 (G/A) polymorphism in CAPN10 gene confers an increased risk of cognitive impairment in cerebral small vessel disease.
|
30014550 |
2018 |
|
Colon Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results indicate a recessive model for the effect of CAPN10 variant UCSNP-44 influencing the risk of CRC and suggest a novel genetic link between T2DM and colon carcinoma.
|
17559371 |
2007 |
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Given that CRC and IR physiologically overlap and the calpain-10 gene (CAPN10) is a candidate for IR, we explored the association between CAPN10 and CRC risk.
|
24377587 |
2014 |
|
Colorectal Carcinoma
|
0.330 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Colorectal Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results indicate a recessive model for the effect of CAPN10 variant UCSNP-44 influencing the risk of CRC and suggest a novel genetic link between T2DM and colon carcinoma.
|
17559371 |
2007 |
|
Colorectal Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
ADIPOQ rs2241766, ADIPOQ rs1501299 and CAPN-10 rs3792267 are significantly associated with CRC risk and the combination of the three polymorphisms and red meat affect CRC risk.
|
26203767 |
2015 |
|
Colorectal Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility.
|
17559371 |
2007 |
|
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The study involved a monogenic analysis of CYP21A2 in patients (375 nonclassical 21OHD [NC21OHD] children; 306 hyperandrogenic 21OHD carriers, n = 306) and a polygenic association study (CAPN10-UCSNP44, PON1-108, TNFR2-M196R, IGF2-ApaI and IRS1-G972R polymorphisms) of 170 hyperandrogenic carriers plus 277 family members (control groups).
|
19039234 |
2009 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study.
|
15793266 |
2005 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study.
|
15793266 |
2005 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study.
|
15793266 |
2005 |