|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The semi-quantitative denaturating high performance liquid chromatography (DHPLC) method was used to detect CNVs in the region of CAPN10 Indel19 marker in cohort of 305 patients with type 2 diabetes and 250 control subjects without diabetes.
|
22796443 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
CAPN10 association with CIMT was replicated, further supporting its role as a common genetic determinant of diabetes and atherosclerosis in Hispanics.
|
19193380 |
2009 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 222 T2DM patients with a diabetes duration of 10 years or more and 206 healthy controls were enrolled to analyze the frequency distribution of four CAPN10 polymorphisms (UCSNP-43, UCSNP-19, UCSNP-110 and UCSNP-63) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in the Tunisian population.
|
18487065 |
2008 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the prevalence of common polymorphisms that have been associated with diseases, such as atherosclerosis (ALOX5), hypertension (CYP3A5, AGT, GNB3), diabetes (CAPN10, TCF7L2, PTPN22), prostate cancer (DG8S737, rs1447295), Hirschsprung disease (RET), and age-related macular degeneration (CFH, LOC387715).
|
18248681 |
2008 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we did not observe any significant associations of the common SNPs or haplotypes across the CAPN10 gene with diabetes risk in our large and ethnically diverse cohort of postmenopausal women.
|
17855447 |
2007 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that CAPN10 gene variations might play roles in the risk of diabetes and hypertension in northern Han Chinese population.
|
18167206 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some genes that have become accepted as contributors to diabetes risk include: calpain 10, peroxisome proliferator-activated receptor-gamma, ATP-sensitive inwardly rectifying potassium channel subunit Kir6.2, hepatocyte nuclear factor 4alpha and hepatic transcription factor 1.
|
17331067 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calpain-10 and calpain-3 and the diabetes ankyrin repeat protein (DARP) have all been linked to insulin resistance and type 2 diabetes.
|
17305703 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calpain-10 was first identified through a genome scan seeking to identify diabetes predisposition genes.
|
17560157 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our observations suggest that UCSNP-19 of CAPN10 may be involved in the pathogenesis of diabetes in CF.
|
16377260 |
2006 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SNP-43 of CAPN10 may contribute to the risk of diabetes by regulating abdominal obesity in subjects with high risk of type 2 diabetes.
|
16752174 |
2006 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.
|
16632098 |
2006 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Calpain-10 (CAPN10) was the first gene for type 2 diabetes identified by positional cloning, wherein a combination of haplotypes conferred increased risk of diabetes.
|
15793266 |
2005 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CAPN10 showed a significant deficit of variation in the haplotype class defined by the derived allele at SNP44, a polymorphism that is significantly associated with diabetes in meta-analysis studies.
|
15696418 |
2005 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
From a total of 26 studies with primary data (21 population-based studies: 5,013 cases and 5,876 controls; 5 family-based studies: 487 parent-offspring trios), we developed a summary database that contains variables of study design, study population/ethnicity, specific polymorphisms and haplotype combinations in CAPN10, and diabetes-related metabolic phenotypes.
|
14730479 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling.
|
14749260 |
2004 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We typed three single nucleotide polymorphisms (SNPs) in the calpain-10 gene (SNPs 43, 56, and 63) to test for association between variation at these loci and type 2 diabetes and diabetes-related traits in 1,603 Finnish subjects: two samples of 526 (Finland-U.S. Investigation of NIDDM Genetics [FUSION] 1) and 255 (FUSION 2) index case subjects with type 2 diabetes, 185 and 414 unaffected spouses and offspring of FUSION 1 index case subjects or their affected siblings, and 223 elderly normal glucose-tolerant control subjects.
|
11978669 |
2002 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that CAPN10 is a diabetes susceptibility locus in Caucasian families at high risk for T2DM, we examined the influence of the three previously implicated CAPN10 variants on both diabetes risk and measures of insulin sensitivity and glucose homeostasis.
|
11836299 |
2002 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variation within the calpain-10 gene (CAPN10) has been proposed to account for linkage to type 2 diabetes on chromosome 2q in Mexican-Americans, and associations with diabetes have been reported in several other populations.
|
12050223 |
2002 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In some populations, Calpain 10 gene polymorphisms increase susceptibility to diabetes or insulin resistance.
|
12107735 |
2002 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because of the high frequency of the G allele (0.88), approximately 25% of the susceptibility to type 2 diabetes in African-Americans may be attributed to the G/G genotype at SNP43 of CAPN10, although most of the subjects with the G/G genotype did not develop diabetes over the 9 years of follow-up.
|
11756346 |
2002 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In 743 sib pairs, there was no evidence of linkage at the CAPN10 locus, which thereby excluded it as a diabetes-susceptibility gene, with an overall sib recurrence risk, lambda(S), of 1.25.
|
11481585 |
2001 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10).
|
11017071 |
2000 |