Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> CSF levels of NFL and CHI3L1 were higher in MS patients compared to non-MS controls.
|
31608004 |
2019 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CHI3L1 levels were similar between RRMS patients in relapse and remission.
|
22183936 |
2012 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS).
|
28063616 |
2017 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHI3L1 may help distinguishing between acute disseminated encephalomyelitis and multiple sclerosis, but this needs further confirmation.
|
30055504 |
2018 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An increase in YKL-40 levels seems to correlate with disease severity and poor prognosis in many diseases, including several neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease (AD).
|
25024322 |
2014 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cerebrospinal fluid chitinase 3-like 1 levels were also measured in a second validation clinically isolated syndrome cohort and found to be increased in patients who converted to multiple sclerosis compared with patients who remained as having clinically isolated syndrome (P=0.018).
|
20237129 |
2010 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cerebrospinal fluid CHI3L1 levels did not influence conversion to clinically isolated syndrome and multiple sclerosis in radiologically isolated syndrome patients.
|
29452342 |
2018 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CSF sCD163 and CHI3L1 levels was significant higher in CIS patients who converted to MS (p < 0.05).
|
31394405 |
2019 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS.
|
29797629 |
2018 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization (ISH) showed CHI3L1 transcription mostly associated with reactive astrocytes, that was more pronounced in inflammatory conditions like lentiviral encephalitis and MS.
|
20540736 |
2010 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic value of cerebrospinal fluid neurofilament light chain and chitinase-3-like-1 in newly diagnosed patients with multiple sclerosis.
|
30113249 |
2019 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Chitinase 3-like protein 1 was increased in ten original articles on MS and in three on AD supporting its implication in these diseases.
|
31220951 |
2019 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The secreted protein, YKL-40, has been proposed as a biomarker of a variety of human diseases characterized by ongoing inflammation, including chronic neurologic pathologies such as multiple sclerosis and Alzheimer's disease.
|
25681350 |
2015 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have previously reported that YKL-40 levels are elevated in the cerebrospinal fluid (CSF) of macaques and humans with lentiviral encephalitis, as well as multiple sclerosis (MS).
|
20486806 |
2010 |