CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE <b>Results:</b> CSF levels of NFL and CHI3L1 were higher in MS patients compared to non-MS controls. 31608004 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE CHI3L1 levels were similar between RRMS patients in relapse and remission. 22183936 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). 28063616 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE CHI3L1 may help distinguishing between acute disseminated encephalomyelitis and multiple sclerosis, but this needs further confirmation. 30055504 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE An increase in YKL-40 levels seems to correlate with disease severity and poor prognosis in many diseases, including several neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease (AD). 25024322 2014
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE Cerebrospinal fluid chitinase 3-like 1 levels were also measured in a second validation clinically isolated syndrome cohort and found to be increased in patients who converted to multiple sclerosis compared with patients who remained as having clinically isolated syndrome (P=0.018). 20237129 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE Cerebrospinal fluid CHI3L1 levels did not influence conversion to clinically isolated syndrome and multiple sclerosis in radiologically isolated syndrome patients. 29452342 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE CSF sCD163 and CHI3L1 levels was significant higher in CIS patients who converted to MS (p < 0.05). 31394405 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE High levels of CSF CHI3L1 and NF-L are associated with cognitive impairment in the early phases of MS. 29797629 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE In situ hybridization (ISH) showed CHI3L1 transcription mostly associated with reactive astrocytes, that was more pronounced in inflammatory conditions like lentiviral encephalitis and MS. 20540736 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE Prognostic value of cerebrospinal fluid neurofilament light chain and chitinase-3-like-1 in newly diagnosed patients with multiple sclerosis. 30113249 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE The Chitinase 3-like protein 1 was increased in ten original articles on MS and in three on AD supporting its implication in these diseases. 31220951 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 Biomarker disease BEFREE The secreted protein, YKL-40, has been proposed as a biomarker of a variety of human diseases characterized by ongoing inflammation, including chronic neurologic pathologies such as multiple sclerosis and Alzheimer's disease. 25681350 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 AlteredExpression disease BEFREE We have previously reported that YKL-40 levels are elevated in the cerebrospinal fluid (CSF) of macaques and humans with lentiviral encephalitis, as well as multiple sclerosis (MS). 20486806 2010