CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE YKL-40 up-regulated VEGF expression in glioblastoma cell line U87, and both YKL-40 and VEGF synergistically promote endothelial cell angiogenesis. 21385870 2011
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Meta-analysis of those studies showed that high YKL-40 expression was associated with worse overall survival in glioblastoma patients (HR = 1.46, 95%CI 1.33-1.61, P < 0.001). 27090900 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells. 15771622 2005
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE In glioblastoma metastasis, the malignant mGSC cells express markers of mesenchymal GSC subtype (MES-GSC), such as CD44 and YK-40 and their major obstacle seems to be propagating in the in various organs' microenvironments, different from the niches that home GSCs in the primary glioblastoma. 31654711 2020
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 GeneticVariation disease BEFREE Taken together our data suggest that the variant allele (-131C-->G) of CHI3L1 promoter has no significant impact on survival and is not a prognostic factor for glioblastoma. 19255724 2009
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE The objective of this study was to evaluate, in a series of 43 pediatric high-grade gliomas (21 anaplastic astrocytoma WHO grade III and 22 glioblastoma WHO grade IV), the prognostic value of histological grading and expression of p53 and YKL-40. 20174854 2010
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE YKL-40 expression was also compared with genetically defined subsets of glioblastoma by assessing epidermal growth factor receptor amplification and loss at chromosome 10q, two of the common recurring aberrations in these tumors, using fluorescent in situ hybridization. 15867231 2005
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE YKL-40 staining in situ was more abundant in glioblastoma tissue than in anaplastic astrocytoma, with the lowest level in normal brain tissue. 25629266 2014
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE We hypothesized that patients with newly diagnosed glioblastoma and low baseline plasma YKL-40 levels derive greater benefit from first-line bevacizumab. 29467925 2018
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE Previous studies have demonstrated that glioblastoma stem cells give rise to endothelial cells through an YKL-40 influence. 28430288 2017
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma 		0.010 Biomarker disease BEFREE 1) CHI3L1 promoted cancer cell proliferation by regulating cell cycles; 2) CHI3L1 promoted cancer cell invasion and metastasis; 3) CHI3L1 regulate liver cancer potentially by regulating the TGF-β signaling pathways; 4) CHI3L1 has direct kinase activities or activate kinase to phosphorylate SMAD2, SMAD3. 30301907 2018
CUI: C0741260
Disease: Adult onset asthma
Adult onset asthma 		0.010 AlteredExpression disease BEFREE Our findings may indicate the presence of a specific endotype related to exaggerated activation of YKL-40 in the pathogenesis of late-onset adult asthma. 30940096 2019
CUI: C0221056
Disease: Adult type dermatomyositis
Adult type dermatomyositis 		0.020 Biomarker disease BEFREE Elevated serum YKL-40 correlates with clinical characteristics in patients with polymyositis or dermatomyositis. 30019588 2019
CUI: C0221056
Disease: Adult type dermatomyositis
Adult type dermatomyositis 		0.020 AlteredExpression disease BEFREE Serum YKL-40 level is associated with severity of interstitial lung disease and poor prognosis in dermatomyositis with anti-MDA5 antibody. 30739212 2019
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 Biomarker disease BEFREE Thus, miR-24 and CHI3L1 might be the targets for developing more effective therapy for degenerative retinal diseases like AMD. 31491426 2019
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 AlteredExpression disease BEFREE The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. 12657616 2003
CUI: C0699949
Disease: airway disease
airway disease 		0.020 Biomarker disease BEFREE However, asthma phenotypes associated with YKL-40 levels have not been precisely defined.We conducted an unsupervised cluster analysis of asthma patients treated at the Yale Center for Asthma and Airways Disease (n=156) to identify subgroups according to YKL-40 level. 29025889 2017
CUI: C0699949
Disease: airway disease
airway disease 		0.020 GeneticVariation disease BEFREE SNPs spanning the CHI3L1 gene were genotyped in 259 Yale Center for Asthma and Airways Disease and 919 Severe Asthma Research Program subjects. 25592985 2015
CUI: C0001883
Disease: Airway Obstruction
Airway Obstruction 		0.010 AlteredExpression group BEFREE An airway transcriptome analysis in C3 and C4 showed activation of non-type 2 inflammatory pathways.Elevated serum YKL-40 levels were associated with two distinct clinical asthma phenotypes: one with irreversible airway obstruction and another with severe exacerbations. 29025889 2017
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.010 Biomarker disease BEFREE During follow-up, the biomarkers of alcohol consumption, GT and CDT, in AUD patients were found to decrease in parallel with serum YKL-40 levels. 30769022 2019
CUI: C0270726
Disease: Alexander Disease
Alexander Disease 		0.010 Biomarker disease BEFREE Transcriptomic analyses of AxD astrocytes and postmortem brains identified CHI3L1 as a key mediator of AxD astrocyte-induced inhibition of OPC activity. 30075130 2018
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 Biomarker disease BEFREE CCL18, chitotriosidase (CHIT1) and YKL-40 are readily detectable in the lungs and contribute to remodelling in other fibrotic diseases, but their involvement in allergic asthma is unclear. 23331560 2013
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.020 AlteredExpression disease BEFREE CC10 can inhibit the expression of chitinase 3-like 1 protein and osteopontin in eosinophilic CRS and allergic rhinitis, respectively. 23242114 2013
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.020 AlteredExpression disease BEFREE YKL-40 is up-regulated in mild and moderate/severe persistent allergic rhinitis, and its expression can be regulated differentially by different cytokines, possibly contributing to the remodeling of nasal mucosa in allergic rhinitis. 24119600 2014
CUI: C3662483
Disease: Allergic sensitization
Allergic sensitization 		0.010 Biomarker disease BEFREE SNPs in CHI3L1 and cord blood YKL-40 were not associated with lung function measurements at 5 weeks and 6 years, respiratory symptoms in the first year, and allergic sensitisation at 6 years. 27193312 2016