CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.350 Biomarker disease BEFREE Sensitivity of serum CTX-II combined with YKL-40 in the diagnosis of OA was 90% and the specificity was 78%. 30651816 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.350 AlteredExpression disease BEFREE By contrast, the immunoexpression and the mRNA levels of CHI3L1 increased in OA cartilage and decreased in normal cartilage (normal vs. OA, p < 0.01). 26978347 2016
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.350 PosttranslationalModification disease BEFREE IL-1 stimulation of OA FLS did not affect methylation of LINE1 sites but led to demethylation of a CHI3L1 locus that is hypomethylated in RA FLS. 23277489 2013
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.350 Biomarker disease BEFREE Serum levels of molecular biomarkers of cartilage metabolism (collagen type II markers: C-terminal neoepitope generated by the collagenase-mediated cleavage of collagen type II triple helix (C2C), collagen type II (Coll2-1, and its nitrated form, Coll2-1NO(2)), procollagen type II (CPII)), synovial metabolism (hyaluronic acid (HA)) and cartilage and synovial turnover (cartilage glycoprotein 39 (YKL-40)) were analysed in 73 patients with OA and 77 healthy controls using ELISAs. 19934106 2010
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.350 Biomarker disease CTD_human Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance. 18784066 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.350 Biomarker disease BEFREE To evaluate the possible utility of YKL-40 in the assessment of joint disease, we measured YKL-40 in serum and SF of 49 patients with various forms of inflammatory and degenerative joint disease and in the serum of 50 normal adults. 8220933 1993