CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Multivariate Cox regression analyses showed that elevated YKL-40 (hazard ratio (HR) = 5.6, P = 0.001), elevated glucose (HR = 3.6, P = 0.001), and schizophrenia diagnosis (HR = 3.0, P = 0.014) at baseline were associated with subsequent development of type 2 diabetes. 30328100 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Further studies are required to perceive a role of YKL-40 and MCP-1 in the initiation and progression of schizophrenia. 30132802 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 AlteredExpression disease BEFREE We hypothesized that higher serum YKL-40 levels are associated with personality trait in patients with schizophrenia. 22366530 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Here we report that CHI3L1 SNPs, shown to be involved in the predisposition of schizophrenia, are not associated with rheumatoid arthritis. 20300754 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Allelic expression imbalance of the schizophrenia susceptibility gene CHI3L1: evidence of cis-acting variation and tissue specific regulation. 21642896 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations. 20051317 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE These results suggest that the genetic contribution of CHI3L1 to schizophrenia is variable, even though it is mechanistically involved in the disease process. 18767121 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE These findings support a functional mechanism for involvement of CHI3L1 in schizophrenia susceptibility, possibly contributing to a less severe illness. 18281018 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease LHGDN Our findings identify CHI3L1 as a potential schizophrenia-susceptibility gene and suggest that the genes involved in the biological response to adverse environmental conditions are likely to play roles in the predisposition to schizophrenia. 17160890 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Our findings identify CHI3L1 as a potential schizophrenia-susceptibility gene and suggest that the genes involved in the biological response to adverse environmental conditions are likely to play roles in the predisposition to schizophrenia. 17160890 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 AlteredExpression disease BEFREE To identify genes associated with schizophrenia, DNA microarray chips were used to compare schizophrenia and control hippocampus tissues, revealing four genes with elevated expression, chondrex (or YKL-40), histamine-releasing factor, HERC2, and heat-shock 70. 12872291 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease CTD_human
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease HPO