|
Kidney Failure, Acute
|
0.310 |
Biomarker
|
disease |
CTD_human |
FSTL1 has previously been implicated in diverse disease processes as a regulator of inflammatory cytokine expression, and we therefore evaluated the response of the genetrap strain to cisplatin-mediated acute kidney injury, a disease model with highly cytokine-dependent pathology.
|
20861081 |
2010 |
|
Kidney Failure, Acute
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
FSTL1 has previously been implicated in diverse disease processes as a regulator of inflammatory cytokine expression, and we therefore evaluated the response of the genetrap strain to cisplatin-mediated acute kidney injury, a disease model with highly cytokine-dependent pathology.
|
20861081 |
2010 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs rs17578796 and rs1700 in hsa-mir-206 (mir-206) and hsa-mit-198 (mir-198) showed nominal significant allelic association to schizophrenia in the Danish and Norwegian sample respectively (P = 0.0021 & p = 0.038), of which only rs17578796 was significant in the joint sample.
|
17849003 |
2007 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Two SNPs rs17578796 and rs1700 in hsa-mir-206 (mir-206) and hsa-mit-198 (mir-198) showed nominal significant allelic association to schizophrenia in the Danish and Norwegian sample respectively (P = 0.0021 & p = 0.038), of which only rs17578796 was significant in the joint sample.
|
17849003 |
2007 |
|
Systemic Scleroderma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors.
|
27482699 |
2016 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Aortic Valve Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
Usefulness of carvedilol in the treatment of chronic aortic valve regurgitation.
|
21216836 |
2011 |
|
Acute Kidney Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
Follistatin-like 1 regulates renal IL-1β expression in cisplatin nephrotoxicity.
|
20861081 |
2010 |
|
Acute kidney injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
FSTL1 has previously been implicated in diverse disease processes as a regulator of inflammatory cytokine expression, and we therefore evaluated the response of the genetrap strain to cisplatin-mediated acute kidney injury, a disease model with highly cytokine-dependent pathology.
|
20861081 |
2010 |
|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
|
19030233 |
2008 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein and mRNA abundance of MIB1 was determined using western blotting and RT‑qPCR respectively, while miR‑198 binding to MIB1 was validated using a luciferase reporter assay. miR‑198 abundance was lower in high Gleason grade prostate cancer relative to intermediate and low‑grade cancer.
|
31322262 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Subsequently, FSTL‑1 inhibition by small interfering RNA significantly reduced cancer cell survival and induced cytotoxic effects.
|
31578589 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we aim to investigate the role of miR-198, a broad-spectrum tumor suppressor, in gastric cancer (GC).
|
31138759 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Results showed that miR-198-5p was under-expressed in NSCLC tissues and was negatively correlated with tumour size, lymph node metastasis and tumour-node-metastasis stage, while FUT8 expression was highly upregulated.
|
31381176 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo tumor formation in athymic nude mice was examined using LNCaP xenografts with stable overexpression conferred using lentiviral miR‑198 transduction.
|
31322262 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For this purpose, a tumor suppressor miRNA (miR-198), deregulated in several human cancer types, was chosen as the model oligonucleotide.
|
30765836 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Results showed that miR-198-5p overexpression could inhibit the migration, invasion and epithelial-to-mesenchymal transition (EMT) of NSCLC cells; reversely, suppression of miR-198-5p enhanced cell migration, invasion and EMT.
|
31381176 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The results showed that circRAPGEF5 was upregulated in PTC tissues and cell lines. circRAPGEF5 knockdown inhibited cell proliferation, migration, and invasion in vitro; and circRAPGEF5 silencing downregulated fibroblast growth factor receptor 1 (FGFR1) expression by "sponging" miR-198, suppressing the aggressive biological behaviors of PTC.
|
30785065 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiR-198 inhibited cancer by suppressing the expression of MYC in liver neoplasm.
|
30378283 |
2018 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hence, a full investigation of the biological roles and regulatory mechanisms of miRNAs in RB may provide novel therapeutic targets for patients with this malignancy. miR‑198 is frequently abnormally expressed in various types of human cancers.
|
29749457 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein that has been shown to play a role in various types of cancer.
|
30275855 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In vivo study indicated that the silencing of hsa_circ_0025039 inhibits melanoma tumor formation and downregulates miR-198 and CDK4 expression.
|
30219673 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A significant increase of FSTL1 was seen in human CRC as compared to the surrounding non-tumor tissues and this occurred at both RNA and protein level.
|
30131854 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FSTL1 plays a tumor suppression role possibly via repressing the NF-κB and HIF-2α signaling pathways.
|
29357946 |
2018 |