Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings further support the role of the ADAMTS7 locus in promoting atherosclerosis in LAs of the brain.
|
31679296 |
2019 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of our study indicate that rs3825807 has an effect on ADAMTS7 maturation, thrombospondin-5 cleavage, and VSMC migration, with the variant associated with protection from atherosclerosis and CAD rendering a reduction in ADAMTS7 function.
|
23415669 |
2013 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis.
|
28623250 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.
|
25712206 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variation at the <i>ADAMTS7</i> locus is associated with several complementary CAD phenotypes, supporting the emerging role of ADAMTS7 in atherosclerosis and may represent a potential drug target.
|
29089340 |
2017 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study attempted to replicate the results for eight of these loci, CDKN2A/B(rs1333049), ADTRP(rs6903956), PDGFD(rs974819), TCF21(rs12190287), COL4A1-A2(rs4773144), HHIPL1(rs2895811), ADAMTS7(rs4380028) and UBE2Z(rs46522), in patients with pathologically defined atherosclerosis of the coronary arteries.
|
24573017 |
2014 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAMTS7 is strongly associated with coronary artery disease and promotes atherosclerosis.
|
29885460 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ADAMTS-7 expression correlates with atherosclerosis and vascular calcification in both human genome-wide association studies and in vivo mice models via COMP-dependent and COMP-independent mechanisms.
|
28155614 |
2017 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, this study was designed to evaluate the effect of rs3825807, a non-synonymous variant in the prodomain of the ADAMTS7 protease, on CAD risk and atherosclerosis severity in a Chinese population.
|
26189211 |
2016 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The native overfunctional ADAMTS7 allele (A) may accelerate VSMC migration and lead to neointimal thickening, atherosclerosis progression and acute plaque events.
|
27614204 |
2016 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies (GWAS) indicated that polymorphisms in ADAMTS7 were associated with artery disease caused by atherosclerosis.
|
31651847 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because delayed endothelium repair renders neointima and atherosclerosis plaque formation after vessel injury, we examined whether ADAMTS-7 also inhibits re-endothelialization.
|
25712208 |
2015 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, genome-wide association studies revealed a relationship between single nucleotide polymorphisms (SNPs) in ADAMTS7 (a disintegrin and metalloprotease with thrombospondin motif 7) and atherosclerosis.
|
28205274 |
2018 |