Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE RASSF1A gene transfected the bladder cancer cells by lipofectamine. 31500788 2019
Malignant neoplasm of urinary bladder
0.400 PosttranslationalModification disease BEFREE Three of the strong evidence associations involve RASSF1 methylation on bladder cancer risk (OR = 18.46; 95% CI: 12.69-26.85; I<sup>2</sup> = 0%), MGMT methylation on NSCLC (OR = 4.25; 95% CI: 2.83-6.38; I<sup>2</sup> = 22.4%) and RARB methylation on prostate cancer (OR = 6.87; 95% CI: 4.68-10.08; I<sup>2</sup> = 0%). 31202904 2019
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE Next, hmDNA levels (RASSF1A qMSP) in stored urine samples of patients suffering from bladder cancer (n = 10) or non-small cell lung cancer (NSCLC; n = 10) were measured at day 0 and 7 upon storage with and without the addition of 40mM EDTA and/or 20 μl/ml Penicillin Streptomycin (PenStrep) at RT and 4°C. 30142219 2018
Malignant neoplasm of urinary bladder
0.400 PosttranslationalModification disease BEFREE There was a significant relationship between the methylation of the RASSF1A gene promoter and bladder cancer. 28207521 2017
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE We hypothesize that this BBN-induced RGS6 loss represents a critical hit in UBC as it irrevocably impairs the anti-proliferative actions of the ATM/p53 and RASSF1A pathways. 27713144 2016
Malignant neoplasm of urinary bladder
0.400 PosttranslationalModification disease BEFREE This study showed that RASSF1A methylation appears to be an independent prognostic factor for bladder cancer. 23139773 2012
Malignant neoplasm of urinary bladder
0.400 PosttranslationalModification disease BEFREE The aim of the present study was to investigate the value of RASSF1A methylation as a prognostic marker in BC. 22382007 2012
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE Promoter hypermethylation occurred frequently in both pathologically normal urothelium and tumor samples from bladder cancer patients, and increased with progression from normal to bladder cancer at E-cadherin (P = 0.067), p16 (P < 0.001), p14 (P = 0.01), and RASSF1A (P = 0.01). 20800513 2012
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE Methylation-specific PCR (MSP) assay was used to detect promoter hypermethylation in 4 genes (E-cadherin, p16, p14, and RASSF1A) to identify reliable biomarkers for bladder cancer diagnosis in primary tumor DNA and urine sediment DNA from 57 bladder cancer patients. 19181545 2011
Malignant neoplasm of urinary bladder
0.400 PosttranslationalModification disease BEFREE There was no association between MTHFR gene variants and methylation status of the RASSF1A gene in the 45 bladder cancer patients in whom this was studied. 20146887 2010
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE RASSF1a/APC/p14, RAR_/DAPK/E-cadh/p16, p16/p14/MGMT/GSTP1, and RASSF1a/E-cadh/APC) are of interest in the detection of bladder cancer. 19522860 2009
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE To investigate the effect of 5-Aza-CdR on methylation and expression of RASSF1A gene in the human bladder cancer BIU87 cell line. 19172108 2009
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE Although no statistically significant differences were found between RARB and RASSF1A methylation and the clinical and histopathological parameters in bladder cancer, a sensitivity of 95% and a specificity of 71% were observed for RARB methylation (Fisher's Exact test (p < 0.0001; OR = 48.89) and, 58% and 17% (p < 0.05; OR = 0.29) for RASSF1A gene, respectively, in relation to the control group. 18702824 2008
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE We, therefore, examined, in a population-based study of human bladder cancer (n = 351), the relationship between epigenetic silencing of the tumor-suppressor genes, p16(INK4A), RASSF1A, PRSS3, and the four SFRP genes and exposure to both tobacco and arsenic in bladder cancer. 17119258 2006
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE A quantitative fluorogenic real-time polymerase chain reaction (PCR) assay was used to examine primary tumor DNA and urine sediment DNA from 15 patients with bladder cancer and 25 control subjects for promoter hypermethylation of nine genes (APC, ARF, CDH1, GSTP1, MGMT, CDKN2A, RARbeta2, RASSF1A, and TIMP3) to identify potential biomarkers for bladder cancer. 16849682 2006
Malignant neoplasm of urinary bladder
0.400 Biomarker disease CTD_human Promoter methylation of each of these genes occurred in approximately 30% of bladder cancers, and both RASSF1A and PRSS3 promoter methylation were associated with advanced tumor stage (P<0.001 and P<0.04, respectively). 15987713 2006
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE We, therefore, examined, in a population-based study of human bladder cancer, the relationship between epigenetic silencing of three tumor suppressor genes, p16(INK4A), RASSF1A and PRSS3, and exposure to both tobacco and arsenic in bladder cancer. 15987713 2006
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE We aimed to investigate the methylation status of RASSF1A and the frequency of LOH in 3p21.3 region in bladder cancer. 12594816 2003