Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 Biomarker disease CTD_human On the basis of this knowledge, we demonstrate how the loss of RASSF1A function in medulloblastoma cells might be overcome using the novel BH3-only mimetic ABT-737 in combination with chemotherapeutic agents to target the BCL-2 anti-apoptotic members. 21880625 2011
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 Biomarker disease BEFREE On the basis of this knowledge, we demonstrate how the loss of RASSF1A function in medulloblastoma cells might be overcome using the novel BH3-only mimetic ABT-737 in combination with chemotherapeutic agents to target the BCL-2 anti-apoptotic members. 21880625 2011
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 PosttranslationalModification disease BEFREE RASSF1A methylation was detected in 19 of 21 MB cases (91%) and in five of six sPNET samples (83%). 17899687 2007
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 AlteredExpression disease BEFREE Treatment of cell lines using 5-Aza-2'-deoxycytidine (5AZA) alone or in combination with trichostatin A (TSA) succeeded in re-establishing expression of RASSF1A in cell lines derived from a renal rhabdoid, an AT/RT and a medulloblastoma. 16186793 2006
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 PosttranslationalModification disease BEFREE The frequency of promoter hypermethylation of RASSF1A was significantly lower in SPNETs than in MBs (Fisher exact test, P = .014). 16311119 2005
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 PosttranslationalModification disease BEFREE These data therefore indicate that extensive methylation of RASSF1A, HIC1 and CASP8 are tumour-specific events in medulloblastoma. 14688019 2004
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 Biomarker disease BEFREE Methylation of the promoter CpG islands of the RASSF1A may play an important role in the pathogenesis of glioma and medulloblastoma. 14586413 2003
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.370 PosttranslationalModification disease BEFREE Furthermore, RASSF1A hypermethylation is a frequent event in medulloblastoma tumorigenesis detectable in adult (5 of 7) and pediatric patients (22 of 27) and in all histological variants and age and sex groupings. 12384556 2002