WIF1, WNT inhibitory factor 1, 11197

N. diseases: 171; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.320 Biomarker group BEFREE The methylation of three Wnt inhibitors, SFRP2, SFRP5, and WIF1, upstream genes in Wnt pathway, and PAX6a, a developmental regulator, was modulated in a protective direction by BRBs in normal tissues and in colorectal tumors only in patients who received BRB treatment for an average of 4 weeks, but not in all 20 patients with 1-9 weeks of BRB treatment. 21123457 2011
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.320 Biomarker group CTD_human The promoter hypermethylation and expression of sFRP and WIF-1 genes in different stages of colorectal tumor and colorectal cancer cell lines were detected by methylation-specific PCR and reverse transcription PCR, respectively. 17923031 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.320 PosttranslationalModification group BEFREE Furthermore, while for both SFRP-1 and WIF-1 methylation-associated silencing occurred across the whole spectrum of colorectal tumorigenesis, DKK-1 promoter was selectively hypermethylated in advanced colorectal neoplasms (Duke's C and D tumors). 16491118 2006