WIF1, WNT inhibitory factor 1, 11197

N. diseases: 171; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 Biomarker disease BEFREE This newly identified INTS6/WIF-1 axis indicates the molecular mechanism of HCC and may represent a therapeutic target in HCC patients. 28899352 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 Biomarker disease BEFREE The aim of the present study was to investigate the effect of anti-estrogen treatment (fulvestrant) on the biological activity of hepatocellular carcinoma (HCC), involving the estrogen receptor α (ERα) and Wnt pathways, and to evaluate whether ERα and Wnt inhibitory factor-1 (WIF1) could be biomarkers for anti-estrogen clinical therapy. 25270093 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 PosttranslationalModification disease BEFREE We found that the sFRP1 gene encoding the subunit is a frequent target of aberrant DNA hypermethylation and silencing in HCC tumours, whereas other extracellular Wnt antagonists, WIF1 and Dkk3, exhibited no methylation in tumour cells, consistent with the notion that aberrant methylation events in cancer cells are non-randomly distributed among the genes and that there is a strong preference for hypermethylation of specific genes in HCC. 22351518 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 AlteredExpression disease BEFREE DNA hypermethylation of WIF-1 promoter was identified in the other four HCC cell lines without WIF-1 expression. 21052890 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 PosttranslationalModification disease BEFREE WIF-1 silencing as a result of its promoter hypermethylation may be a frequent event in HCC. 20119713 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 PosttranslationalModification disease BEFREE The methylation of DKK-3 and WIF-1 genes in HCC increased significantly compared with adjacent non-cancerous tissues and normal control tissues (chi(2) =7.79, P < 0.05; chi(2) = 4.89, P < 0.05), and no significant difference in methylation between adjacent non-cancerous tissues and normal control tissues was observed. 19496188 2009