Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
|
10617473 |
1999 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.
|
11719428 |
2001 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.
|
11967536 |
2002 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
CHEK2 is a multiorgan cancer susceptibility gene.
|
15492928 |
2004 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
CHEK2 1100delC and male breast cancer in the Netherlands.
|
18759107 |
2009 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Synergistic interaction of variants in CHEK2 and BRCA2 on breast cancer risk.
|
19030985 |
2009 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer.
|
20722467 |
2010 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.
|
21244692 |
2011 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer.
|
21876083 |
2011 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
CHEK2*1100delC and risk of malignant melanoma: Danish and German studies and meta-analysis.
|
21956126 |
2012 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
|
22006311 |
2011 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
A risk of essential thrombocythemia in carriers of constitutional CHEK2 gene mutations.
|
22058216 |
2012 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women.
|
22058428 |
2011 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Frequency of the CHEK2 1100delC mutation among women with early-onset and bilateral breast cancer.
|
22520019 |
2012 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases.
|
22691310 |
2012 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma.
|
22811390 |
2013 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.
|
22994785 |
2012 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.
|
23109706 |
2012 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.
|
23329222 |
2012 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles.
|
23409019 |
2013 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases.
|
23415889 |
2013 |
Nephroblastoma
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.
|
24723567 |
2014 |