|
Malignant neoplasm of prostate
|
0.310 |
Biomarker
|
disease |
BEFREE |
Because AKAP plays a major role in protein kinase A and Rho protein mediated signaling, functional studies are underway to elucidate the significance of tTG-AKAP13 interaction in prostate cancer.
|
16301118 |
2006 |
|
Coronary Artery Disease
|
0.110 |
Biomarker
|
disease |
BEFREE |
In contrast, three hub genes including PLEKHG5 (T2D: OR=1, P=1; CAD: OR=1.12, P=0.006), TIAM1 (T2D: OR=1, P=1; CAD: OR=1.48, P=0.004) and AKAP13 (T2D: OR=1, P=1; CAD: OR=1.38, P=0.001) were hub genes unique to CAD.
|
24508273 |
2014 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Thus, genetic alterations within the candidate cancer susceptibility gene AKAP13 would be expected to provoke a constitutive Rho signalling, thereby facilitating the development of cancer.
|
16234258 |
2006 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In a first phase, the LBC ONC characterized the phenotype and molecular aberration profiles of LSC in various malignancies.
|
30006759 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We used LBC, based on SurePathTM (BD Diagnostics) technology, to screen 96 peritoneal fluid samples from patients with known malignancies and from 10 control patients with cirrhosis.
|
30024911 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.
|
26578795 |
2015 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
These data suggest that AKAP13 was expressed in relation with ROCK1/2, which probably play an overall role in both mucosal healing and tumorigenesis.
|
28434818 |
2017 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
18381585 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear.
|
17918192 |
2008 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, genetic alterations within the candidate cancer susceptibility gene AKAP13 would be expected to provoke a constitutive Rho signalling, thereby facilitating the development of cancer.
|
16234258 |
2006 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
In 2008 the Ludwig Boltzmann Cluster Oncology (LBC ONC) was established on the basis of two previous Ludwig Boltzmann Institutes working in the field of hematology and cancer research.
|
30006759 |
2018 |
|
Malignant neoplasm of breast
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
We show that the PKA-anchoring protein AKAP13 is essential for the phosphorylation of ERαS305, which leads to tamoxifen resistance both in cell lines and tamoxifen-treated breast cancer patients.
|
26272591 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, the significant modulation and good diagnostic performances of glutamate, N-acetyl glycoprotein and Lactate in LBC as compared to EBC give their significance in the BC progression.
|
30059813 |
2018 |
|
Malignant neoplasm of breast
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here, we discovered that carriers of both variants, AKAP10 Ile646Val and AKAP13 Lys526Gln, are at a further enhanced breast cancer risk (OR=2.41, 95% CI 1.30-4.46, P=0.005).
|
16956908 |
2007 |
|
Breast Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here, we discovered that carriers of both variants, AKAP10 Ile646Val and AKAP13 Lys526Gln, are at a further enhanced breast cancer risk (OR=2.41, 95% CI 1.30-4.46, P=0.005).
|
16956908 |
2007 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Furthermore, the significant modulation and good diagnostic performances of glutamate, N-acetyl glycoprotein and Lactate in LBC as compared to EBC give their significance in the BC progression.
|
30059813 |
2018 |
|
Breast Carcinoma
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
We show that the PKA-anchoring protein AKAP13 is essential for the phosphorylation of ERαS305, which leads to tamoxifen resistance both in cell lines and tamoxifen-treated breast cancer patients.
|
26272591 |
2015 |
|
Chronic granulomatous disease
|
0.020 |
AlteredExpression
|
group |
BEFREE |
This observation suggests that patients with CGD may also have a defect in lymphocyte function. p47 protein and mRNA levels increase during retinoic acid-induced neutrophil differentiation of HL60 cells.
|
2398896 |
1990 |
|
Chronic granulomatous disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
A male CGD patient with pg91(phox) deficiency exhibited a trend toward prolongation of this calcium response, whereas two other CGD patients (one with p47 and one with 67(phox) deficiencies) had normal calcium transients.
|
15527168 |
2004 |
|
Malaria
|
0.020 |
Biomarker
|
disease |
BEFREE |
These key functions make Plasmodium P47 an attractive target to disrupt malaria transmission.
|
29229188 |
2017 |
|
Malaria
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data establish a dual role of P. berghei P47 in vivo and reinforce the use of this parasite to study the impact of the mosquito immune response on human malaria transmission.
|
28729672 |
2017 |