Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.050 AlteredExpression disease BEFREE Knockdown of GALNT6 in breast cancer cell attenuated the protein expression of PCNA, cyclin D1, C-myc and β-catenin, and increased the expression of E-cadherin, caspase 3 and cleaved PARP1. 30662357 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.050 AlteredExpression disease BEFREE Knockdown of GALNT6 expression in two breast cancer cell lines, T47D and MCF7, in which both ER-α and GALNT6 were highly expressed, by small interfering RNA could significantly attenuate expression of ER-α. 30208353 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.050 Biomarker disease BEFREE We previously suggested that polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6), which catalyzes O-type glycosylation of Mucin 1, might be a promising molecular target for drug development for breast cancer. 27237318 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.050 Biomarker disease BEFREE Our findings implied that overexpression of GALNT6 might contribute to mammary carcinogenesis through aberrant glycosylation and stabilization of MUC1 and that screening of GALNT6 inhibitors would be valuable for the development of novel therapeutic modalities against breast cancer. 20215525 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.050 AlteredExpression disease BEFREE Thus, we selected this enzyme as a target gene for further evaluation. ppGalNAc-T6 mRNA was found in 22/25 (88%) breast cancer samples, in all 3 human breast cancer cell lines evaluated (MCF-7, ZR75-1 and T47D), in 1/30 (3%) PBMN cells and 0/19 bone marrow samples obtained from patients without cancer. 16596643 2006