RNF139, ring finger protein 139, 11236

N. diseases: 36; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease HPO
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease CTD_human
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.410 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 GeneticVariation disease BEFREE A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. 17539022 2007
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 Biomarker disease BEFREE TRC8 encodes an E3-ubiquitin ligase disrupted in a family with hereditary renal cell carcinoma (RCC). 15735686 2005
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 Biomarker disease CTD_human
CUI: C1266042
Disease: Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1266043
Disease: Sarcomatoid Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1266044
Disease: Collecting Duct Carcinoma of the Kidney
Collecting Duct Carcinoma of the Kidney 		0.300 Biomarker disease CTD_human
CUI: C1306837
Disease: Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma 		0.300 Biomarker disease CTD_human
CUI: C1333985
Disease: Hereditary clear cell renal cell carcinoma
Hereditary clear cell renal cell carcinoma 		0.300 FusionGene disease ORPHANET
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. 17016439 2007
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 GeneticVariation disease BEFREE The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an endoplasmic reticulum-resident E3 ligase. 22689053 2013
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. 15735686 2005
CUI: C0740457
Disease: Malignant neoplasm of kidney
Malignant neoplasm of kidney 		0.040 Biomarker disease BEFREE Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. 12032852 2002
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 GeneticVariation disease BEFREE The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an endoplasmic reticulum-resident E3 ligase. 22689053 2013
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 Biomarker disease BEFREE Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. 15735686 2005
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 Biomarker disease BEFREE RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. 17016439 2007
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.040 Biomarker disease BEFREE Thus, VHL, TRC8, and JAB1 appear to be linked both physically and functionally and all three may participate in the development of kidney cancer. 12032852 2002
CUI: C0013377
Disease: Dysgerminoma
Dysgerminoma 		0.020 GeneticVariation disease BEFREE As the tumor suppressor gene TRC8/RNF139 is disrupted by constitutional t(8;22)(q24.13;q11.21) in dysgerminoma, it may be associated with the onset of CML. 27686674 2017
CUI: C0013377
Disease: Dysgerminoma
Dysgerminoma 		0.020 Biomarker disease BEFREE TRC8 was strongly underexpressed in the dysgerminoma. 19642973 2009
CUI: C2931852
Disease: Clear-cell metastatic renal cell carcinoma
Clear-cell metastatic renal cell carcinoma 		0.020 GeneticVariation disease BEFREE Haploinsufficiency of TRC8 may facilitate development of clear cell-RCC in association with VHL mutations, and may increase risk for other tumor types. 19642973 2009
CUI: C2931852
Disease: Clear-cell metastatic renal cell carcinoma
Clear-cell metastatic renal cell carcinoma 		0.020 GeneticVariation disease BEFREE These results confirm that balanced translocations disrupting the TRC8 and FHIT genes result in an increased genetic susceptibility for bilateral CC-RCC. 17539022 2007
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell 		0.020 Biomarker disease BEFREE We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched. 9689122 1998
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell 		0.020 Biomarker disease BEFREE RNF139/TRC8 is a potential tumor suppressor gene with similarity to PTCH, a tumor suppressor implicated in basal cell carcinomas and glioblastomas. 19642973 2009