Obesity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Do allelic variants of SLC6A14 predispose to obesity?
|
14660737 |
2003 |
Obesity
|
0.030 |
Biomarker
|
disease |
BEFREE |
The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control.
|
14660752 |
2003 |
Acidosis
|
0.200 |
Biomarker
|
phenotype |
RGD |
Stimulation of intestinal glutamine absorption in chronic metabolic acidosis.
|
15300171 |
2004 |
Obesity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these data confirm an association of the SLC6A14 gene locus with obesity.
|
15331564 |
2004 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans.
|
15905073 |
2005 |
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans.
|
15905073 |
2005 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans.
|
15905073 |
2005 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans.
|
15905073 |
2005 |
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix.
|
16168467 |
2006 |
Sarcoma, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Stimulation of expression of the intestinal glutamine transporter ATB0 in tumor-bearing rats.
|
17006743 |
2006 |
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
RGD |
Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes.
|
17065219 |
2006 |
Ulcerative Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Microarray analysis has shown that the expression of transcripts aldolase B, elafin, MST-1, simNIPhom and SLC6A14 are altered in patients with ulcerative colitis.
|
18334872 |
2008 |
Ulcerative Colitis
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Five mucosal transcripts of interest in ulcerative colitis identified by quantitative real-time PCR: a prospective study.
|
18700007 |
2008 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that the transporter is up-regulated specifically in estrogen receptor (ER)-positive breast cancer, demonstrable with primary human breast cancer tissues and human breast cancer cell lines.SLC6A14 is an estrogen/ER target.
|
21771784 |
2011 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that the transporter is up-regulated specifically in estrogen receptor (ER)-positive breast cancer, demonstrable with primary human breast cancer tissues and human breast cancer cell lines.SLC6A14 is an estrogen/ER target.
|
21771784 |
2011 |
Oestrogen receptor positive breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, treatment of ER-positive breast cancer cells in vitro with α-methyl-DL-tryptophan (α-MT), a selective blocker of SLC6A14, induces amino acid deprivation, inhibits mTOR, and activates autophagy.
|
21771784 |
2011 |
Intestinal Obstruction
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis.
|
22466613 |
2012 |
CYSTIC FIBROSIS MODIFIER 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis.
|
22466613 |
2012 |
Cystic Fibrosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
We sought to determine whether SLC26A9, SLC9A3 and SLC6A14, that contribute to meconium ileus in CF, are pleiotropic for other early-affecting CF co-morbidities.
|
24057835 |
2014 |
Lung diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
SLC26A9 was pleiotropic for meconium ileus and pancreatic damage (p = 0.002 at rs7512462), SLC9A3 for meconium ileus and lung disease (p = 1.5 × 10(-6) at rs17563161), and SLC6A14 for meconium ileus and both lung disease and age at first P. aeruginosa infection (p = 0.0002 and p = 0.006 at rs3788766, respectively).
|
24057835 |
2014 |
Meconium ileus
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
SLC26A9 was pleiotropic for meconium ileus and pancreatic damage (p = 0.002 at rs7512462), SLC9A3 for meconium ileus and lung disease (p = 1.5 × 10(-6) at rs17563161), and SLC6A14 for meconium ileus and both lung disease and age at first P. aeruginosa infection (p = 0.0002 and p = 0.006 at rs3788766, respectively).
|
24057835 |
2014 |
Pancreatic Ductal Adenocarcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma.
|
26106611 |
2015 |
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SLC6A14 was overexpressed at the transcriptional level in all patients and expressed at the protein level in 95% of PDAC tumors.
|
26106611 |
2015 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Very little is known about the role of SLC6A14 in PDAC and our results demonstrate that this target merits further investigation as a candidate transporter for functional imaging of PDAC.
|
26106611 |
2015 |
Cystic Fibrosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Regions on chr3q29 (MUC4/MUC20; P=3.3 × 10(-11)), chr5p15.3 (SLC9A3; P=6.8 × 10(-12)), chr6p21.3 (HLA Class II; P=1.2 × 10(-8)) and chrXq22-q23 (AGTR2/SLC6A14; P=1.8 × 10(-9)) contain genes of high biological relevance to CF pathophysiology.
|
26417704 |
2015 |