CHRM2, cholinergic receptor muscarinic 2, 1129

N. diseases: 91; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.400 GeneticVariation disease BEFREE (d) Examination of family-based samples has identified several genes including GABRA2 and CHRM2 thought to be associated with alcohol dependence. 16612210 2006
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.320 Biomarker group BEFREE CHRM2 was defined as a candidate gene for nicotine addiction based on previous evidence that linked variations in CHRM2 to alcohol and drug dependence. 19644963 2010
CUI: C0028754
Disease: Obesity
Obesity 		0.020 Biomarker disease BEFREE CHRM2 genotypic variance predicted longitudinal BMI and obesity status. 25155933 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia. 27923235 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.020 GeneticVariation disease BEFREE p.R270H (rs116454156) in the long chain fatty acid 7TM receptor FFAR4 (GPR120) which results in impaired Gαq (Gq) coupled signalling, has been associated with obesity. 27068006 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.040 GeneticVariation disease BEFREE A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. 19181679 2009
CUI: C0340427
Disease: Familial dilated cardiomyopathy
Familial dilated cardiomyopathy 		0.020 GeneticVariation disease BEFREE A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. 18451336 2008
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.010 GeneticVariation group LHGDN A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. 18451336 2008
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.310 Biomarker disease CTD_human Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. 18333967 2008
CUI: C0086237
Disease: Epilepsy, Cryptogenic
Epilepsy, Cryptogenic 		0.300 Biomarker disease CTD_human Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. 18333967 2008
CUI: C0236018
Disease: Aura
Aura 		0.300 Biomarker phenotype CTD_human Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. 18333967 2008
CUI: C0751111
Disease: Awakening Epilepsy
Awakening Epilepsy 		0.300 Biomarker disease CTD_human Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. 18333967 2008
CUI: C0038580
Disease: Substance Dependence
Substance Dependence 		0.320 Biomarker disease CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.320 Biomarker group CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.300 Biomarker group CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0013170
Disease: Drug habituation
Drug habituation 		0.300 Biomarker phenotype CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0013222
Disease: Drug Use Disorders
Drug Use Disorders 		0.300 Biomarker group CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0029231
Disease: Organic Mental Disorders, Substance-Induced
Organic Mental Disorders, Substance-Induced 		0.300 Biomarker disease CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0038586
Disease: Substance Use Disorders
Substance Use Disorders 		0.300 Biomarker group CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0236969
Disease: Substance-Related Disorders
Substance-Related Disorders 		0.300 Biomarker group CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0740858
Disease: Substance abuse problem
Substance abuse problem 		0.300 Biomarker disease CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C4316881
Disease: Prescription Drug Abuse
Prescription Drug Abuse 		0.300 Biomarker phenotype CTD_human Altered neural cholinergic receptor systems in cocaine-addicted subjects. 20393457 2010
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.010 Biomarker disease BEFREE An antibody for the muscarinic M2 receptor is related to atrial fibrillation, an antibody targeting Na-K-ATPase is closely related to sudden cardiac death from fatal ventricular arrhythmias, and an autoantibody for troponin I increases the L-type calcium current and is related to myocardial damage. 21617318 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.400 Biomarker disease LHGDN Association analyses of a candidate gene, CHRM2, previously of interest in the Collaborative Study on the Genetics of Alcoholism, suggest that it is involved in a general externalizing phenotype. 18316677 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.040 Biomarker disease BEFREE Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women. 12116189 2002